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The First Norovirus Longitudinal Seroepidemiological Study From Sub-Saharan Africa Reveals High Seroprevalence of Diverse Genotypes Associated With Host Susceptibility Factors

BACKGROUND: Human noroviruses (HuNoVs) are a prominent cause of gastroenteritis, yet fundamental questions remain regarding epidemiology, diversity, and immunity in sub-Saharan African children. We investigated HuNoV seroprevalence and genetic and sociodemographic risk factors in Ugandan children. M...

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Autores principales: Thorne, Lucy, Nalwoga, Angela, Mentzer, Alexander J, de Rougemont, Alexis, Hosmillo, Myra, Webb, Emily, Nampiija, Margaret, Muhwezi, Allan, Carstensen, Tommy, Gurdasani, Deepti, Hill, Adrian V, Sandhu, Manj S, Elliott, Alison, Goodfellow, Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057498/
https://www.ncbi.nlm.nih.gov/pubmed/29912471
http://dx.doi.org/10.1093/infdis/jiy219
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author Thorne, Lucy
Nalwoga, Angela
Mentzer, Alexander J
de Rougemont, Alexis
Hosmillo, Myra
Webb, Emily
Nampiija, Margaret
Muhwezi, Allan
Carstensen, Tommy
Gurdasani, Deepti
Hill, Adrian V
Sandhu, Manj S
Elliott, Alison
Goodfellow, Ian
author_facet Thorne, Lucy
Nalwoga, Angela
Mentzer, Alexander J
de Rougemont, Alexis
Hosmillo, Myra
Webb, Emily
Nampiija, Margaret
Muhwezi, Allan
Carstensen, Tommy
Gurdasani, Deepti
Hill, Adrian V
Sandhu, Manj S
Elliott, Alison
Goodfellow, Ian
author_sort Thorne, Lucy
collection PubMed
description BACKGROUND: Human noroviruses (HuNoVs) are a prominent cause of gastroenteritis, yet fundamental questions remain regarding epidemiology, diversity, and immunity in sub-Saharan African children. We investigated HuNoV seroprevalence and genetic and sociodemographic risk factors in Ugandan children. METHODS: We randomly screened 797 participants of a longitudinal birth cohort (Entebbe, EMaBS) and 378 from a cross-sectional survey (rural Lake Victoria, LaVIISWA), for antibodies against HuNoV genotypes by ELISA. We used linear regression modeling to test for associations between HuNoV antibody levels and sociodemographic factors, and with the human susceptibility rs601338 FUT2 secretor SNP and histo-blood group antigens (A/B/O). RESULTS: Of EMaBS participants, 76.6% were seropositive by age 1, rising to 94.5% by age 2 years. Seroprevalence in 1 year olds of the rural LaVIISWA survey was even higher (95%). In the birth cohort, 99% of seropositive 2 year olds had responses to multiple HuNoV genotypes. We identified associations between secretor status and genogroup GII antibody levels (GII.4 P = 3.1 × 10(−52)), as well as ABO and GI (GI.2 P = 2.1 × 10(−12)). CONCLUSIONS: HuNoVs are highly prevalent in Ugandan children, indicating a substantial burden of diarrhea-associated morbidity with recurrent infections. Public health interventions, including vaccination, and increased surveillance are urgently needed.
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spelling pubmed-60574982018-07-27 The First Norovirus Longitudinal Seroepidemiological Study From Sub-Saharan Africa Reveals High Seroprevalence of Diverse Genotypes Associated With Host Susceptibility Factors Thorne, Lucy Nalwoga, Angela Mentzer, Alexander J de Rougemont, Alexis Hosmillo, Myra Webb, Emily Nampiija, Margaret Muhwezi, Allan Carstensen, Tommy Gurdasani, Deepti Hill, Adrian V Sandhu, Manj S Elliott, Alison Goodfellow, Ian J Infect Dis Major Articles and Brief Reports BACKGROUND: Human noroviruses (HuNoVs) are a prominent cause of gastroenteritis, yet fundamental questions remain regarding epidemiology, diversity, and immunity in sub-Saharan African children. We investigated HuNoV seroprevalence and genetic and sociodemographic risk factors in Ugandan children. METHODS: We randomly screened 797 participants of a longitudinal birth cohort (Entebbe, EMaBS) and 378 from a cross-sectional survey (rural Lake Victoria, LaVIISWA), for antibodies against HuNoV genotypes by ELISA. We used linear regression modeling to test for associations between HuNoV antibody levels and sociodemographic factors, and with the human susceptibility rs601338 FUT2 secretor SNP and histo-blood group antigens (A/B/O). RESULTS: Of EMaBS participants, 76.6% were seropositive by age 1, rising to 94.5% by age 2 years. Seroprevalence in 1 year olds of the rural LaVIISWA survey was even higher (95%). In the birth cohort, 99% of seropositive 2 year olds had responses to multiple HuNoV genotypes. We identified associations between secretor status and genogroup GII antibody levels (GII.4 P = 3.1 × 10(−52)), as well as ABO and GI (GI.2 P = 2.1 × 10(−12)). CONCLUSIONS: HuNoVs are highly prevalent in Ugandan children, indicating a substantial burden of diarrhea-associated morbidity with recurrent infections. Public health interventions, including vaccination, and increased surveillance are urgently needed. Oxford University Press 2018-09-01 2018-04-18 /pmc/articles/PMC6057498/ /pubmed/29912471 http://dx.doi.org/10.1093/infdis/jiy219 Text en © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Major Articles and Brief Reports
Thorne, Lucy
Nalwoga, Angela
Mentzer, Alexander J
de Rougemont, Alexis
Hosmillo, Myra
Webb, Emily
Nampiija, Margaret
Muhwezi, Allan
Carstensen, Tommy
Gurdasani, Deepti
Hill, Adrian V
Sandhu, Manj S
Elliott, Alison
Goodfellow, Ian
The First Norovirus Longitudinal Seroepidemiological Study From Sub-Saharan Africa Reveals High Seroprevalence of Diverse Genotypes Associated With Host Susceptibility Factors
title The First Norovirus Longitudinal Seroepidemiological Study From Sub-Saharan Africa Reveals High Seroprevalence of Diverse Genotypes Associated With Host Susceptibility Factors
title_full The First Norovirus Longitudinal Seroepidemiological Study From Sub-Saharan Africa Reveals High Seroprevalence of Diverse Genotypes Associated With Host Susceptibility Factors
title_fullStr The First Norovirus Longitudinal Seroepidemiological Study From Sub-Saharan Africa Reveals High Seroprevalence of Diverse Genotypes Associated With Host Susceptibility Factors
title_full_unstemmed The First Norovirus Longitudinal Seroepidemiological Study From Sub-Saharan Africa Reveals High Seroprevalence of Diverse Genotypes Associated With Host Susceptibility Factors
title_short The First Norovirus Longitudinal Seroepidemiological Study From Sub-Saharan Africa Reveals High Seroprevalence of Diverse Genotypes Associated With Host Susceptibility Factors
title_sort first norovirus longitudinal seroepidemiological study from sub-saharan africa reveals high seroprevalence of diverse genotypes associated with host susceptibility factors
topic Major Articles and Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057498/
https://www.ncbi.nlm.nih.gov/pubmed/29912471
http://dx.doi.org/10.1093/infdis/jiy219
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