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Germline and somatic mtDNA mutations in mouse aging

The accumulation of acquired mitochondrial genome (mtDNA) mutations with aging in somatic cells has been implicated in mitochondrial dysfunction and linked to age-onset diseases in humans. Here, we asked if somatic mtDNA mutations are also associated with aging in the mouse. MtDNA integrity in multi...

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Detalles Bibliográficos
Autores principales:	Ma, Hong, Lee, Yeonmi, Hayama, Tomonari, Van Dyken, Crystal, Marti-Gutierrez, Nuria, Li, Ying, Ahmed, Riffat, Koski, Amy, Kang, Eunju, Darby, Hayley, Gonmanee, Thanasup, Park, Younjung, Wolf, Don P., Jai Kim, Chong, Mitalipov, Shoukhrat
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057648/ https://www.ncbi.nlm.nih.gov/pubmed/30040856 http://dx.doi.org/10.1371/journal.pone.0201304

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