Cargando…

MiR-361-3p regulates ERK1/2-induced EMT via DUSP2 mRNA degradation in pancreatic ductal adenocarcinoma

Metastasis remains one of the most intractable challenges in pancreatic ductal adenocarcinoma (PDAC) biology, and epithelial-to-mesenchymal transition (EMT) is essential to the epithelium-originated solid tumor metastasis cascade. Emerging evidence demonstrates that aberrant miRNA expression is invo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hu, Jisheng, Li, Le, Chen, Hongze, Zhang, Guangquan, Liu, Huan, Kong, Rui, Chen, Hua, Wang, Yongwei, Li, Yilong, Tian, Fengyu, Lv, Xinjian, Li, Guanqun, Sun, Bei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057920/ https://www.ncbi.nlm.nih.gov/pubmed/30042387 http://dx.doi.org/10.1038/s41419-018-0839-8

Ejemplares similares

UBL4A inhibits autophagy-mediated proliferation and metastasis of pancreatic ductal adenocarcinoma via targeting LAMP1
por: Chen, Hongze, et al.
Publicado: (2019)

Overexpression of KLF5 is associated with poor survival and G1/S progression in pancreatic cancer
por: Li, Yilong, et al.
Publicado: (2019)

Lnc-PFAR facilitates autophagy and exacerbates pancreatic fibrosis by reducing pre-miR-141 maturation in chronic pancreatitis
por: Zhang, Tao, et al.
Publicado: (2021)

Tumor Cell Derived Lnc‐FSD2‐31:1 Contributes to Cancer‐Associated Fibroblasts Activation in Pancreatic Ductal Adenocarcinoma Progression through Extracellular Vesicles Cargo MiR‐4736
por: Geng, Xinglong, et al.
Publicado: (2023)

Regulation of atypical MAP kinases ERK3 and ERK4 by the phosphatase DUSP2
por: Perander, Maria, et al.
Publicado: (2017)

MicroRNA-361-5p Inhibits Tumorigenesis and the EMT of HCC by Targeting Twist1
por: Yin, Liang-Chun, et al.
Publicado: (2020)

DUSP6 expression is associated with osteoporosis through the regulation of osteoclast differentiation via ERK2/Smad2 signaling
por: Zhang, Boya, et al.
Publicado: (2021)

Silencing IGFBP-2 decreases pancreatic cancer metastasis and enhances chemotherapeutic sensitivity
por: Liu, Huan, et al.
Publicado: (2017)

CIC Is a Mediator of the ERK1/2-DUSP6 Negative Feedback Loop
por: Ren, Yibo, et al.
Publicado: (2020)

A positive feedback loop of ARF6 activates ERK1/2 signaling pathway via DUSP6 silencing to promote pancreatic cancer progression : ARF6 regulates ERK1/2 pathway by inhibiting DUSP6
por: Xiao, Bingkai, et al.
Publicado: (2022)

Beneficial Diets and Pancreatic Cancer: Molecular Mechanisms and Clinical Practice
por: Zhang, Yang, et al.
Publicado: (2021)

Cancer-Associated Fibroblast (CAF) Heterogeneity and Targeting Therapy of CAFs in Pancreatic Cancer
por: Geng, Xinglong, et al.
Publicado: (2021)

DUSP7 regulates the activity of ERK2 to promote proper chromosome alignment during cell division
por: Guo, Xiao, et al.
Publicado: (2021)

NKX2-1 controls lung cancer progression by inducing DUSP6 to dampen ERK activity
por: Ingram, Kelley, et al.
Publicado: (2021)

Dual-specificity phosphatase (DUSP6) in human glioblastoma: epithelial-to-mesenchymal transition (EMT) involvement
por: Zuchegna, Candida, et al.
Publicado: (2020)

Dihydroartemisinin suppresses pancreatic cancer cells via a microRNA-mRNA regulatory network
por: Li, Yilong, et al.
Publicado: (2016)

DUSP5 and DUSP6, two ERK specific phosphatases, are markers of a higher MAPK signaling activation in BRAF mutated thyroid cancers
por: Buffet, Camille, et al.
Publicado: (2017)

Dusp6 Inhibits Epithelial-mesenchymal Transition in Endometrial Adenocarcinoma Via ERK Signaling Pathway
por: Fan, Ming-Jun, et al.
Publicado: (2019)

Positive feedback regulation of lncRNA TPT1‐AS1 and ITGB3 promotes cell growth and metastasis in pancreatic cancer
por: Cheng, Chundong, et al.
Publicado: (2022)

circEIF3I facilitates the recruitment of SMAD3 to early endosomes to promote TGF-β signalling pathway-mediated activation of MMPs in pancreatic cancer
por: Zhao, Zhongjie, et al.
Publicado: (2023)

Activation of ERK1/2 Causes Pazopanib Resistance via Downregulation of DUSP6 in Synovial Sarcoma Cells
por: Yokoyama, Nobuhiko, et al.
Publicado: (2017)

The SKA3-DUSP2 Axis Promotes Gastric Cancer Tumorigenesis and Epithelial-Mesenchymal Transition by Activating the MAPK/ERK Pathway
por: Zhang, Chao, et al.
Publicado: (2022)

Overexpression of DUSP6 enhances chemotherapy-resistance of ovarian epithelial cancer by regulating the ERK signaling pathway
por: Gao, Yan, et al.
Publicado: (2020)

The Anti-Apoptotic and Cardioprotective Effects of Salvianolic Acid A on Rat Cardiomyocytes following Ischemia/Reperfusion by DUSP-Mediated Regulation of the ERK1/2/JNK Pathway
por: Xu, Tongda, et al.
Publicado: (2014)

The MAPK/ERK Pathway and the Role of DUSP1 in JCPyV Infection of Primary Astrocytes
por: Wilczek, Michael P., et al.
Publicado: (2021)

DNTTIP1 promotes nasopharyngeal carcinoma metastasis via recruiting HDAC1 to DUSP2 promoter and activating ERK signaling pathway
por: Ding, Shirong, et al.
Publicado: (2022)

BAF53A drives colorectal cancer development by regulating DUSP5-mediated ERK phosphorylation
por: Yang, Ziqing, et al.
Publicado: (2022)

Vasoactive intestinal peptide controls the suprachiasmatic circadian clock network via ERK1/2 and DUSP4 signalling
por: Hamnett, Ryan, et al.
Publicado: (2019)

CCN2-induced lymphangiogenesis is mediated by the integrin αvβ5–ERK pathway and regulated by DUSP6
por: Hashiguchi, Shiho, et al.
Publicado: (2022)

DOCK1 insufficiency disrupts trophoblast function and pregnancy outcomes via DUSP4-ERK pathway
por: Xu, Yichi, et al.
Publicado: (2023)

PKN2 in colon cancer cells inhibits M2 phenotype polarization of tumor-associated macrophages via regulating DUSP6-Erk1/2 pathway
por: Cheng, Yang, et al.
Publicado: (2018)

Girdin interaction with vimentin induces EMT and promotes the growth and metastasis of pancreatic ductal adenocarcinoma
por: Wang, Wulin, et al.
Publicado: (2020)

GLIPR-2 Overexpression in HK-2 Cells Promotes Cell EMT and Migration through ERK1/2 Activation
por: Huang, Shaoguang, et al.
Publicado: (2013)

Cell-in-Cell Phenomenon and Its Relationship With Tumor Microenvironment and Tumor Progression: A Review
por: Wang, Xinlong, et al.
Publicado: (2019)

DUSP5 and DUSP6 modulate corneal epithelial cell proliferation
por: Wang, Zheng, et al.
Publicado: (2010)

Negative-feedback regulation of FGF signalling by DUSP6/MKP-3 is driven by ERK1/2 and mediated by Ets factor binding to a conserved site within the DUSP6/MKP-3 gene promoter
por: Ekerot, Maria, et al.
Publicado: (2008)

Soluble urokinase plasminogen activator receptor associates with higher risk, advanced disease severity as well as inflammation, and might serve as a prognostic biomarker of severe acute pancreatitis
por: Zhang, Qi, et al.
Publicado: (2019)

IPF-Fibroblast Erk1/2 Activity Is Independent from microRNA Cluster 17-92 but Can Be Inhibited by Treprostinil through DUSP1
por: Blumer, Sabrina, et al.
Publicado: (2021)

MicroRNA-361-Mediated Inhibition of HSP90 Expression and EMT in Cervical Cancer Is Counteracted by Oncogenic lncRNA NEAT1
por: Xu, Daozhi, et al.
Publicado: (2020)

Connexin 32 dysfunction promotes ethanol-related hepatocarcinogenesis via activation of Dusp1-Erk axis
por: Kato, Hiroyuki, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_p1hq5cgb67pcmap40fhad4brjt