XAF1 forms a positive feedback loop with IRF-1 to drive apoptotic stress response and suppress tumorigenesis

X-linked inhibitor of apoptosis (XIAP)-associated factor 1 (XAF1) is a proapoptotic tumor suppressor that is frequently inactivated in multiple human cancers. However, the molecular basis for the XAF1-mediated growth inhibition remains largely undefined. Here, we report that XAF1 forms a positive fe...

Descripción completa

Detalles Bibliográficos
Autores principales: Jeong, Seong-In, Kim, Jung-Wook, Ko, Kyung-Phil, Ryu, Byung-Kyu, Lee, Min-Goo, Kim, Hyo-Jong, Chi, Sung-Gil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057933/
https://www.ncbi.nlm.nih.gov/pubmed/30042418
http://dx.doi.org/10.1038/s41419-018-0867-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057933/
https://www.ncbi.nlm.nih.gov/pubmed/30042418
http://dx.doi.org/10.1038/s41419-018-0867-4

Ejemplares similares