Introduction of pathogenic mutations into the mouse Psen1 gene by Base Editor and Target-AID

Base Editor (BE) and Target-AID (activation-induced cytidine deaminase) are engineered genome-editing proteins composed of Cas9 and cytidine deaminases. These base-editing tools convert C:G base pairs to T:A at target sites. Here, we inject either BE or Target-AID mRNA together with identical single...

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Detalles Bibliográficos
Autores principales: Sasaguri, Hiroki, Nagata, Kenichi, Sekiguchi, Misaki, Fujioka, Ryo, Matsuba, Yukio, Hashimoto, Shoko, Sato, Kaori, Kurup, Deepika, Yokota, Takanori, Saido, Takaomi C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057936/
https://www.ncbi.nlm.nih.gov/pubmed/30042426
http://dx.doi.org/10.1038/s41467-018-05262-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057936/
https://www.ncbi.nlm.nih.gov/pubmed/30042426
http://dx.doi.org/10.1038/s41467-018-05262-w

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