The effect of succinate on brain NADH/NAD(+) redox state and high energy phosphate metabolism in acute traumatic brain injury

A key pathophysiological process and therapeutic target in the critical early post-injury period of traumatic brain injury (TBI) is cell mitochondrial dysfunction; characterised by elevation of brain lactate/pyruvate (L/P) ratio in the absence of hypoxia. We previously showed that succinate can impr...

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Detalles Bibliográficos
Autores principales: Stovell, Matthew G., Mada, Marius O., Helmy, Adel, Carpenter, T. Adrian, Thelin, Eric P., Yan, Jiun-Lin, Guilfoyle, Mathew R., Jalloh, Ibrahim, Howe, Duncan J., Grice, Peter, Mason, Andrew, Giorgi-Coll, Susan, Gallagher, Clare N., Murphy, Michael P., Menon, David K., Hutchinson, Peter J., Carpenter, Keri L. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057963/
https://www.ncbi.nlm.nih.gov/pubmed/30042490
http://dx.doi.org/10.1038/s41598-018-29255-3

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