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Macrophages confer resistance to PI3K inhibitor GDC-0941 in breast cancer through the activation of NF-κB signaling

The PI3K pathway is one of the most dysregulated signaling pathways in epithelial cancers and has become an attractive therapeutic target under active preclinical and clinical development. However, recent clinical trial studies revealed that blockade of PI3K activity in advanced cancer often leads t...

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Detalles Bibliográficos
Autores principales:	Usman, Muhammad Waqas, Gao, Jing, Zheng, Tiezheng, Rui, Chunhua, Li, Ting, Bian, Xing, Cheng, Hailing, Liu, Pixu, Luo, Fuwen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057974/ https://www.ncbi.nlm.nih.gov/pubmed/30042442 http://dx.doi.org/10.1038/s41419-018-0849-6

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