Incompatible Translation Drives a Convergent Evolution and Viral Attenuation During the Development of Live Attenuated Vaccine

Live attenuated vaccines are widely used to protect humans or animals from pathogen infections. We have previously developed a chicken embryo-attenuated Duck Hepatitis A Virus genotype 1 (DHAV-1) vaccine (CH60 strain). This study aims to understand the mechanisms that drive a virulent strain to an a...

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Detalles Bibliográficos
Autores principales: Ou, Xumin, Wang, Mingshu, Mao, Sai, Cao, Jingyu, Cheng, Anchun, Zhu, Dekang, Chen, Shun, Jia, Renyong, Liu, Mafeng, Yang, Qiao, Wu, Ying, Zhao, Xinxin, Zhang, Shaqiu, Liu, Yunya, Yu, Yanling, Zhang, Ling, Chen, Xiaoyue, Peppelenbosch, Maikel P., Pan, Qiuwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Cellular and Infection Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058041/
https://www.ncbi.nlm.nih.gov/pubmed/30073153
http://dx.doi.org/10.3389/fcimb.2018.00249

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