DNA methylation analysis on purified neurons and glia dissects age and Alzheimer’s disease-specific changes in the human cortex

BACKGROUND: Epigenome-wide association studies (EWAS) based on human brain samples allow a deep and direct understanding of epigenetic dysregulation in Alzheimer’s disease (AD). However, strong variation of cell-type proportions across brain tissue samples represents a significant source of data noi...

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Detalles Bibliográficos
Autores principales: Gasparoni, Gilles, Bultmann, Sebastian, Lutsik, Pavlo, Kraus, Theo F. J., Sordon, Sabrina, Vlcek, Julia, Dietinger, Vanessa, Steinmaurer, Martina, Haider, Melanie, Mulholland, Christopher B., Arzberger, Thomas, Roeber, Sigrun, Riemenschneider, Matthias, Kretzschmar, Hans A., Giese, Armin, Leonhardt, Heinrich, Walter, Jörn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058387/
https://www.ncbi.nlm.nih.gov/pubmed/30045751
http://dx.doi.org/10.1186/s13072-018-0211-3

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