Detecting Demyelination by PET: The Lesion as Imaging Target

Noninvasive imaging of demyelination and remyelination is critical for diagnosis and clinical management of demyelinating diseases. Positron emission tomography (PET) has the potential to complement magnetic resonance imaging (MRI) by providing a quantitative measure specific to demyelination. In Br...

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Detalles Bibliográficos
Autores principales: Brugarolas, Pedro, Reich, Daniel S., Popko, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058413/
https://www.ncbi.nlm.nih.gov/pubmed/30039728
http://dx.doi.org/10.1177/1536012118785471
Descripción
Sumario:Noninvasive imaging of demyelination and remyelination is critical for diagnosis and clinical management of demyelinating diseases. Positron emission tomography (PET) has the potential to complement magnetic resonance imaging (MRI) by providing a quantitative measure specific to demyelination. In Brugarolas et al’s study(1), we describe the development of the first PET tracer for voltage-gated K(+) channels based on a clinically approved drug for multiple sclerosis that can be used for imaging demyelination in animal models.

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