Detecting Demyelination by PET: The Lesion as Imaging Target

Noninvasive imaging of demyelination and remyelination is critical for diagnosis and clinical management of demyelinating diseases. Positron emission tomography (PET) has the potential to complement magnetic resonance imaging (MRI) by providing a quantitative measure specific to demyelination. In Br...

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Detalles Bibliográficos
Autores principales: Brugarolas, Pedro, Reich, Daniel S., Popko, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2018
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058413/
https://www.ncbi.nlm.nih.gov/pubmed/30039728
http://dx.doi.org/10.1177/1536012118785471
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author Brugarolas, Pedro
Reich, Daniel S.
Popko, Brian
author_facet Brugarolas, Pedro
Reich, Daniel S.
Popko, Brian
author_sort Brugarolas, Pedro
collection PubMed
description Noninvasive imaging of demyelination and remyelination is critical for diagnosis and clinical management of demyelinating diseases. Positron emission tomography (PET) has the potential to complement magnetic resonance imaging (MRI) by providing a quantitative measure specific to demyelination. In Brugarolas et al’s study(1), we describe the development of the first PET tracer for voltage-gated K(+) channels based on a clinically approved drug for multiple sclerosis that can be used for imaging demyelination in animal models.
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spelling pubmed-60584132018-07-27 Detecting Demyelination by PET: The Lesion as Imaging Target Brugarolas, Pedro Reich, Daniel S. Popko, Brian Mol Imaging Commentary Noninvasive imaging of demyelination and remyelination is critical for diagnosis and clinical management of demyelinating diseases. Positron emission tomography (PET) has the potential to complement magnetic resonance imaging (MRI) by providing a quantitative measure specific to demyelination. In Brugarolas et al’s study(1), we describe the development of the first PET tracer for voltage-gated K(+) channels based on a clinically approved drug for multiple sclerosis that can be used for imaging demyelination in animal models. SAGE Publications 2018-07-24 /pmc/articles/PMC6058413/ /pubmed/30039728 http://dx.doi.org/10.1177/1536012118785471 Text en © The Author(s) 2018 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Commentary
Brugarolas, Pedro
Reich, Daniel S.
Popko, Brian
Detecting Demyelination by PET: The Lesion as Imaging Target
title Detecting Demyelination by PET: The Lesion as Imaging Target
title_full Detecting Demyelination by PET: The Lesion as Imaging Target
title_fullStr Detecting Demyelination by PET: The Lesion as Imaging Target
title_full_unstemmed Detecting Demyelination by PET: The Lesion as Imaging Target
title_short Detecting Demyelination by PET: The Lesion as Imaging Target
title_sort detecting demyelination by pet: the lesion as imaging target
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058413/
https://www.ncbi.nlm.nih.gov/pubmed/30039728
http://dx.doi.org/10.1177/1536012118785471
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