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Water-soluble substituted chitosan derivatives as technology platform for inhalation delivery of siRNA

Despite research efforts full potential of siRNA-based therapeutics has not yet been fully realized due to a need for suitable, effective delivery formulations. Here, we examine a potential of a new class of water-soluble chitosans as siRNA platform for pulmonary delivery. The system is based on pip...

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Detalles Bibliográficos
Autores principales: Capel, Victoria, Vllasaliu, Driton, Watts, Peter, Clarke, Philip A., Luxton, Dominic, Grabowska, Anna M., Mantovani, Giuseppe, Stolnik, Snjezana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058492/
https://www.ncbi.nlm.nih.gov/pubmed/29493294
http://dx.doi.org/10.1080/10717544.2018.1440668