Localized co-delivery of collagenase and trastuzumab by thermosensitive hydrogels for enhanced antitumor efficacy in human breast xenograft

Modulation of the collagen-rich extracellular matrix (ECM) in solid tumors by the treatment with collagenase has been proved effective in enhancement of the interstitial transport and antitumor efficacy of antibodies. We, therefore, developed a PLGA-PEG-PLGA polymer-based thermosensitive hydrogel, w...

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Detalles Bibliográficos
Autores principales: Pan, Anni, Wang, Zhaoyang, Chen, Binlong, Dai, Wenbing, Zhang, Hua, He, Bing, Wang, Xueqing, Wang, Yiguang, Zhang, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058501/
https://www.ncbi.nlm.nih.gov/pubmed/29943651
http://dx.doi.org/10.1080/10717544.2018.1474971

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