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Bone-targeted methotrexate–alendronate conjugate inhibits osteoclastogenesis in vitro and prevents bone loss and inflammation of collagen-induced arthritis in vivo

Rheumatoid arthritis (RA), a disease that causes joint destruction and bone erosion, is related to osteoclast activity. RA is generally treated with methotrexate (MTX). In this study, a MTX–Alendronate (ALN) conjugate was synthesized and characterized. The conjugate dramatically inhibited osteoclast...

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Detalles Bibliográficos
Autores principales:	Xie, Zi’ang, Liu, Guanxiong, Tang, Pan, Sun, Xuewu, Chen, Shuai, Qin, An, Zhu, Peizhi, Zhang, Jianfeng, Fan, Shunwu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058523/ https://www.ncbi.nlm.nih.gov/pubmed/29303005 http://dx.doi.org/10.1080/10717544.2017.1422295

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