Regression of Giant Olfactory Groove Meningioma and Complete Visual Acuity Recovery after Discontinuation of Cyproterone Acetate

PURPOSE: To report on the medical management of meningioma with compression of the optic chiasm associated with the use of cyproterone acetate (CA). CASE REPORT: A 65-year-old woman who was being treated with CA presented with a recent decrease in visual function, leading to discovery of a giant olf...

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Detalles Bibliográficos
Autores principales: Bernat, Anne Laure, Bonnin, Sophie, Labidi, Moujahed, Aldahak, Nouman, Bresson, Damien, Bouazza, Schahrazed, Froelich, Sebastien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058554/
https://www.ncbi.nlm.nih.gov/pubmed/30090195
http://dx.doi.org/10.4103/jovr.jovr_21_17
Descripción
Sumario:PURPOSE: To report on the medical management of meningioma with compression of the optic chiasm associated with the use of cyproterone acetate (CA). CASE REPORT: A 65-year-old woman who was being treated with CA presented with a recent decrease in visual function, leading to discovery of a giant olfactory groove meningioma with compression of the optic chiasm. CA was discontinued immediately, and her visual function improved dramatically. At 13 months, in addition to a significant improvement in visual and neurocognitive symptoms, the tumor volume was reduced by 50%. CONCLUSION: In meningiomas associated with CA, treatment cessation may result in prompt improvement in symptoms and a reduction in tumor volume, even if the tumor is large and causing neurologic impairments.

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