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Enhancement of dissolution and oral bioavailability of lacidipine via pluronic P123/F127 mixed polymeric micelles: formulation, optimization using central composite design and in vivo bioavailability study

This study aims at preparing and optimizing lacidipine (LCDP) polymeric micelles using thin film hydration technique in order to overcome LCDP solubility-limited oral bioavailability. A two-factor three-level central composite face-centered design (CCFD) was employed to optimize the formulation vari...

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Detalles Bibliográficos
Autores principales:	Fares, Ahmed R., ElMeshad, Aliaa N., Kassem, Mohamed A. A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058706/ https://www.ncbi.nlm.nih.gov/pubmed/29275642 http://dx.doi.org/10.1080/10717544.2017.1419512

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