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Mass spectrometry-assisted identification of ADAMTS13-derived peptides presented on HLA-DR and HLA-DQ

Formation of microthrombi is a hallmark of acquired thrombotic thrombocytopenic purpura. These microthrombi originate from insufficient processing of ultra large von Willebrand factor multimers by ADAMTS13 due to the development of anti-ADAMTS13 autoantibodies. Several studies have identified the ma...

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Detalles Bibliográficos
Autores principales: Hrdinová, Johana, Verbij, Fabian C., Kaijen, Paul H.P., Hartholt, Robin B., van Alphen, Floris, Lardy, Neubury, ten Brinke, Anja, Vanhoorelbeke, Karen, Hindocha, Pooja J., De Groot, Anne S., Meijer, Alexander B., Voorberg, Jan, Peyron, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058777/
https://www.ncbi.nlm.nih.gov/pubmed/29567779
http://dx.doi.org/10.3324/haematol.2017.179119