BET-inhibition by JQ1 promotes proliferation and self-renewal capacity of hematopoietic stem cells

Although inhibitors of bromodomain and extra terminal domain (BET) proteins show promising clinical activity in different hematologic malignancies, a systematic analysis of the consequences of pharmacological BET inhibition on healthy hematopoietic (stem) cells is urgently needed. We found that JQ1...

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Detalles Bibliográficos
Autores principales: Wroblewski, Mark, Scheller-Wendorff, Marina, Udonta, Florian, Bauer, Raimund, Schlichting, Jara, Zhao, Lin, Ben Batalla, Isabel, Gensch, Victoria, Päsler, Sarina, Wu, Lei, Wanior, Marek, Taipaleenmäki, Hanna, Bolamperti, Simona, Najafova, Zeynab, Pantel, Klaus, Bokemeyer, Carsten, Qi, Jun, Hesse, Eric, Knapp, Stefan, Johnsen, Steven, Loges, Sonja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058788/
https://www.ncbi.nlm.nih.gov/pubmed/29567778
http://dx.doi.org/10.3324/haematol.2017.181354

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