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A novel regimen for relapsed/refractory adult acute myeloid leukemia using a KMT2A partial tandem duplication targeted therapy: results of phase 1 study NCI 8485

KMT2A partial tandem duplication occurs in approximately 5–10% of patients with acute myeloid leukemia and is associated with adverse prognosis. KMT2A wild type is epigenetically silenced in KMT2A partial tandem duplication; re-expression can be induced with DNA methyltransferase and/or histone deac...

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Detalles Bibliográficos
Autores principales:	Mims, Alice S., Mishra, Anjali, Orwick, Shelley, Blachly, James, Klisovic, Rebecca B., Garzon, Ramiro, Walker, Alison R., Devine, Steven M., Walsh, Katherine J., Vasu, Sumithira, Whitman, Susan, Marcucci, Guido, Jones, Daniel, Heerema, Nyla A., Lozanski, Gerard, Caligiuri, Michael A., Bloomfield, Clara D., Byrd, John C., Piekarz, Richard, Grever, Michael R., Blum, William
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ferrata Storti Foundation 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058798/ https://www.ncbi.nlm.nih.gov/pubmed/29567781 http://dx.doi.org/10.3324/haematol.2017.186890

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