Endocardial TRPC-6 Channels Act as Atrial Mechanosensors and Load-Dependent Modulators of Endocardial/Myocardial Cross-Talk

Mechanoelectrical feedback may increase arrhythmia susceptibility, but the molecular mechanisms are incompletely understood. This study showed that mechanical stretch altered the localization, protein levels, and function of the cation-selective transient receptor potential channel (TRPC)-6 in atria...

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Detalles Bibliográficos
Autores principales: Nikolova-Krstevski, Vesna, Wagner, Soeren, Yu, Ze Yan, Cox, Charles D., Cvetkovska, Jasmina, Hill, Adam P., Huttner, Inken G., Benson, Victoria, Werdich, Andreas A., MacRae, Calum, Feneley, Michael P., Friedrich, Oliver, Martinac, Boris, Fatkin, Diane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
PRECLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058914/
https://www.ncbi.nlm.nih.gov/pubmed/30062171
http://dx.doi.org/10.1016/j.jacbts.2017.05.006

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