A Minimally Invasive, Translational Method to Deliver Hydrogels to the Heart Through the Pericardial Space

Biomaterials are a new treatment strategy for cardiovascular diseases but are difficult to deliver to the heart in a safe, precise, and translatable way. We developed a method to deliver hydrogels to the epicardium through the pericardial space. Our device creates a temporary compartment for hydroge...

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Detalles Bibliográficos
Autores principales: Garcia, Jose R., Campbell, Peter F., Kumar, Gautam, Langberg, Jonathan J., Cesar, Liliana, Wang, Lanfang, García, Andrés J., Levit, Rebecca D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
NOVEL TRANSLATIONAL METHOD
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058920/
https://www.ncbi.nlm.nih.gov/pubmed/30062173
http://dx.doi.org/10.1016/j.jacbts.2017.06.003
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author Garcia, Jose R.
Campbell, Peter F.
Kumar, Gautam
Langberg, Jonathan J.
Cesar, Liliana
Wang, Lanfang
García, Andrés J.
Levit, Rebecca D.
author_facet Garcia, Jose R.
Campbell, Peter F.
Kumar, Gautam
Langberg, Jonathan J.
Cesar, Liliana
Wang, Lanfang
García, Andrés J.
Levit, Rebecca D.
author_sort Garcia, Jose R.
collection PubMed
description Biomaterials are a new treatment strategy for cardiovascular diseases but are difficult to deliver to the heart in a safe, precise, and translatable way. We developed a method to deliver hydrogels to the epicardium through the pericardial space. Our device creates a temporary compartment for hydrogel delivery and gelation using anatomic structures. The method minimizes risk to patients from embolization, thrombotic occlusion, and arrhythmia. In pigs there were no clinically relevant acute or subacute adverse effects from pericardial hydrogel delivery, making this a translatable strategy to deliver biomaterials to the heart.
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spelling pubmed-60589202018-07-30 A Minimally Invasive, Translational Method to Deliver Hydrogels to the Heart Through the Pericardial Space Garcia, Jose R. Campbell, Peter F. Kumar, Gautam Langberg, Jonathan J. Cesar, Liliana Wang, Lanfang García, Andrés J. Levit, Rebecca D. JACC Basic Transl Sci NOVEL TRANSLATIONAL METHOD Biomaterials are a new treatment strategy for cardiovascular diseases but are difficult to deliver to the heart in a safe, precise, and translatable way. We developed a method to deliver hydrogels to the epicardium through the pericardial space. Our device creates a temporary compartment for hydrogel delivery and gelation using anatomic structures. The method minimizes risk to patients from embolization, thrombotic occlusion, and arrhythmia. In pigs there were no clinically relevant acute or subacute adverse effects from pericardial hydrogel delivery, making this a translatable strategy to deliver biomaterials to the heart. Elsevier 2017-10-04 /pmc/articles/PMC6058920/ /pubmed/30062173 http://dx.doi.org/10.1016/j.jacbts.2017.06.003 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle NOVEL TRANSLATIONAL METHOD
Garcia, Jose R.
Campbell, Peter F.
Kumar, Gautam
Langberg, Jonathan J.
Cesar, Liliana
Wang, Lanfang
García, Andrés J.
Levit, Rebecca D.
A Minimally Invasive, Translational Method to Deliver Hydrogels to the Heart Through the Pericardial Space
title A Minimally Invasive, Translational Method to Deliver Hydrogels to the Heart Through the Pericardial Space
title_full A Minimally Invasive, Translational Method to Deliver Hydrogels to the Heart Through the Pericardial Space
title_fullStr A Minimally Invasive, Translational Method to Deliver Hydrogels to the Heart Through the Pericardial Space
title_full_unstemmed A Minimally Invasive, Translational Method to Deliver Hydrogels to the Heart Through the Pericardial Space
title_short A Minimally Invasive, Translational Method to Deliver Hydrogels to the Heart Through the Pericardial Space
title_sort minimally invasive, translational method to deliver hydrogels to the heart through the pericardial space
topic NOVEL TRANSLATIONAL METHOD
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058920/
https://www.ncbi.nlm.nih.gov/pubmed/30062173
http://dx.doi.org/10.1016/j.jacbts.2017.06.003
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