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Matrix Signaling Subsequent to a Myocardial Infarction: A Proteomic Profile of Tissue Factor Microparticles
This study investigated the release and proteomic profile of tissue factor microparticles (TFMPs) prospectively (up to 6 months) following a myocardial infarction (MI) in a chronic porcine model to establish their utility in tracking cellular level activities that predict physiologic outcomes. Our a...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058924/ https://www.ncbi.nlm.nih.gov/pubmed/30062169 http://dx.doi.org/10.1016/j.jacbts.2017.04.004 |
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author | Akpalu, Derrick Newman, Gale Brice, Mark Powell, Mike Singh, Rajesh Quarshie, Alexander Ofili, Elizabeth Fonger, James Chronos, Nic Feldman, David |
author_facet | Akpalu, Derrick Newman, Gale Brice, Mark Powell, Mike Singh, Rajesh Quarshie, Alexander Ofili, Elizabeth Fonger, James Chronos, Nic Feldman, David |
author_sort | Akpalu, Derrick |
collection | PubMed |
description | This study investigated the release and proteomic profile of tissue factor microparticles (TFMPs) prospectively (up to 6 months) following a myocardial infarction (MI) in a chronic porcine model to establish their utility in tracking cellular level activities that predict physiologic outcomes. Our animal groups (n = 6 to 8 each) consisted of control, noninfarcted (negative control); infarcted only (positive control); and infarcted animals treated with cardiac resynchronization therapy (CRT) and a β-blocker (BB) (metoprolol succinate). The authors found different protein profiles in TFMPs between the control, infarcted only group, and the CRT + BB treated group with predictive impact on the outward phenotype of pathological remodeling after an MI within and between groups. This novel approach of monitoring cellular level activities by profiling the content of TFMPs has the potential of addressing a shortfall of the current crop of cardiac biomarkers, which is the inability to capture composite molecular changes associated with chronic maladaptive signaling in a spatial and temporal manner. |
format | Online Article Text |
id | pubmed-6058924 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-60589242018-07-30 Matrix Signaling Subsequent to a Myocardial Infarction: A Proteomic Profile of Tissue Factor Microparticles Akpalu, Derrick Newman, Gale Brice, Mark Powell, Mike Singh, Rajesh Quarshie, Alexander Ofili, Elizabeth Fonger, James Chronos, Nic Feldman, David JACC Basic Transl Sci PRECLINICAL RESEARCH This study investigated the release and proteomic profile of tissue factor microparticles (TFMPs) prospectively (up to 6 months) following a myocardial infarction (MI) in a chronic porcine model to establish their utility in tracking cellular level activities that predict physiologic outcomes. Our animal groups (n = 6 to 8 each) consisted of control, noninfarcted (negative control); infarcted only (positive control); and infarcted animals treated with cardiac resynchronization therapy (CRT) and a β-blocker (BB) (metoprolol succinate). The authors found different protein profiles in TFMPs between the control, infarcted only group, and the CRT + BB treated group with predictive impact on the outward phenotype of pathological remodeling after an MI within and between groups. This novel approach of monitoring cellular level activities by profiling the content of TFMPs has the potential of addressing a shortfall of the current crop of cardiac biomarkers, which is the inability to capture composite molecular changes associated with chronic maladaptive signaling in a spatial and temporal manner. Elsevier 2017-10-30 /pmc/articles/PMC6058924/ /pubmed/30062169 http://dx.doi.org/10.1016/j.jacbts.2017.04.004 Text en © 2017 Published by Elsevier on behalf of American College of Cardiology Foundation. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | PRECLINICAL RESEARCH Akpalu, Derrick Newman, Gale Brice, Mark Powell, Mike Singh, Rajesh Quarshie, Alexander Ofili, Elizabeth Fonger, James Chronos, Nic Feldman, David Matrix Signaling Subsequent to a Myocardial Infarction: A Proteomic Profile of Tissue Factor Microparticles |
title | Matrix Signaling Subsequent to a Myocardial Infarction: A Proteomic Profile of Tissue Factor Microparticles |
title_full | Matrix Signaling Subsequent to a Myocardial Infarction: A Proteomic Profile of Tissue Factor Microparticles |
title_fullStr | Matrix Signaling Subsequent to a Myocardial Infarction: A Proteomic Profile of Tissue Factor Microparticles |
title_full_unstemmed | Matrix Signaling Subsequent to a Myocardial Infarction: A Proteomic Profile of Tissue Factor Microparticles |
title_short | Matrix Signaling Subsequent to a Myocardial Infarction: A Proteomic Profile of Tissue Factor Microparticles |
title_sort | matrix signaling subsequent to a myocardial infarction: a proteomic profile of tissue factor microparticles |
topic | PRECLINICAL RESEARCH |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058924/ https://www.ncbi.nlm.nih.gov/pubmed/30062169 http://dx.doi.org/10.1016/j.jacbts.2017.04.004 |
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