Low-Density Lipoprotein Receptor–Related Protein-1 Is a Therapeutic Target in Acute Myocardial Infarction

Low-density lipoprotein receptor–related protein-1 (LRP1) is a ubiquitous membrane receptor functioning as a scavenger and regulatory receptor, inducing anti-inflammatory and prosurvival signals. Based on the known structure–activity of the LRP1 receptor binding site, the authors synthesized a small...

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Autores principales: Toldo, Stefano, Austin, Dana, Mauro, Adolfo G., Mezzaroma, Eleonora, Van Tassell, Benjamin W., Marchetti, Carlo, Carbone, Salvatore, Mogelsvang, Soren, Gelber, Cohava, Abbate, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
PRECLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058925/
https://www.ncbi.nlm.nih.gov/pubmed/30062170
http://dx.doi.org/10.1016/j.jacbts.2017.05.007
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author Toldo, Stefano
Austin, Dana
Mauro, Adolfo G.
Mezzaroma, Eleonora
Van Tassell, Benjamin W.
Marchetti, Carlo
Carbone, Salvatore
Mogelsvang, Soren
Gelber, Cohava
Abbate, Antonio
author_facet Toldo, Stefano
Austin, Dana
Mauro, Adolfo G.
Mezzaroma, Eleonora
Van Tassell, Benjamin W.
Marchetti, Carlo
Carbone, Salvatore
Mogelsvang, Soren
Gelber, Cohava
Abbate, Antonio
author_sort Toldo, Stefano
collection PubMed
description Low-density lipoprotein receptor–related protein-1 (LRP1) is a ubiquitous membrane receptor functioning as a scavenger and regulatory receptor, inducing anti-inflammatory and prosurvival signals. Based on the known structure–activity of the LRP1 receptor binding site, the authors synthesized a small peptide (SP16). SP16 induced a >50% reduction in infarct size (p < 0.001) and preservation of left ventricular systolic function (p < 0.001), and treatment with an LRP1 blocking antibody eliminated the protective effects of SP16. In conclusion, LRP1 activation with SP16 given within 30 min of reperfusion during experimental acute myocardial infarction leads to a cardioprotective signal reducing infarct size and preservation of cardiac systolic function.
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spelling pubmed-60589252018-07-30 Low-Density Lipoprotein Receptor–Related Protein-1 Is a Therapeutic Target in Acute Myocardial Infarction Toldo, Stefano Austin, Dana Mauro, Adolfo G. Mezzaroma, Eleonora Van Tassell, Benjamin W. Marchetti, Carlo Carbone, Salvatore Mogelsvang, Soren Gelber, Cohava Abbate, Antonio JACC Basic Transl Sci PRECLINICAL RESEARCH Low-density lipoprotein receptor–related protein-1 (LRP1) is a ubiquitous membrane receptor functioning as a scavenger and regulatory receptor, inducing anti-inflammatory and prosurvival signals. Based on the known structure–activity of the LRP1 receptor binding site, the authors synthesized a small peptide (SP16). SP16 induced a >50% reduction in infarct size (p < 0.001) and preservation of left ventricular systolic function (p < 0.001), and treatment with an LRP1 blocking antibody eliminated the protective effects of SP16. In conclusion, LRP1 activation with SP16 given within 30 min of reperfusion during experimental acute myocardial infarction leads to a cardioprotective signal reducing infarct size and preservation of cardiac systolic function. Elsevier 2017-10-30 /pmc/articles/PMC6058925/ /pubmed/30062170 http://dx.doi.org/10.1016/j.jacbts.2017.05.007 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle PRECLINICAL RESEARCH
Toldo, Stefano
Austin, Dana
Mauro, Adolfo G.
Mezzaroma, Eleonora
Van Tassell, Benjamin W.
Marchetti, Carlo
Carbone, Salvatore
Mogelsvang, Soren
Gelber, Cohava
Abbate, Antonio
Low-Density Lipoprotein Receptor–Related Protein-1 Is a Therapeutic Target in Acute Myocardial Infarction
title Low-Density Lipoprotein Receptor–Related Protein-1 Is a Therapeutic Target in Acute Myocardial Infarction
title_full Low-Density Lipoprotein Receptor–Related Protein-1 Is a Therapeutic Target in Acute Myocardial Infarction
title_fullStr Low-Density Lipoprotein Receptor–Related Protein-1 Is a Therapeutic Target in Acute Myocardial Infarction
title_full_unstemmed Low-Density Lipoprotein Receptor–Related Protein-1 Is a Therapeutic Target in Acute Myocardial Infarction
title_short Low-Density Lipoprotein Receptor–Related Protein-1 Is a Therapeutic Target in Acute Myocardial Infarction
title_sort low-density lipoprotein receptor–related protein-1 is a therapeutic target in acute myocardial infarction
topic PRECLINICAL RESEARCH
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058925/
https://www.ncbi.nlm.nih.gov/pubmed/30062170
http://dx.doi.org/10.1016/j.jacbts.2017.05.007
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