Protein Kinase C Inhibition With Ruboxistaurin Increases Contractility and Reduces Heart Size in a Swine Model of Heart Failure With Reduced Ejection Fraction

Inotropic support is often required to stabilize the hemodynamics of patients with acute decompensated heart failure; while efficacious, it has a history of leading to lethal arrhythmias and/or exacerbating contractile and energetic insufficiencies. Novel therapeutics that can improve contractility...

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Detalles Bibliográficos
Autores principales: Sharp, Thomas E., Kubo, Hajime, Berretta, Remus M., Starosta, Timothy, Wallner, Markus, Schena, Giana J., Hobby, Alexander R., Yu, Daohai, Trappanese, Danielle M., George, Jon C., Molkentin, Jeffery D., Houser, Steven R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
PRECLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058945/
https://www.ncbi.nlm.nih.gov/pubmed/30062182
http://dx.doi.org/10.1016/j.jacbts.2017.06.007

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