Aggravated Atherosclerosis and Vascular Inflammation With Reduced Kidney Function Depend on Interleukin-17 Receptor A and Are Normalized by Inhibition of Interleukin-17A

Effective therapy of atherosclerotic complications in patients with chronic kidney disease (CKD) is an unmet clinical need. Cardiovascular events are the most common cause of death. At a glomerular filtration rate ≤60 ml/min, these events are increased also after correction for common risk factors....

Descripción completa

Detalles Bibliográficos
Autores principales: Nordlohne, Johannes, Helmke, Alexandra, Ge, Shuwang, Rong, Song, Chen, Rongjun, Waisman, Ari, Haller, Hermann, von Vietinghoff, Sibylle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
PRECLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058956/
https://www.ncbi.nlm.nih.gov/pubmed/30062194
http://dx.doi.org/10.1016/j.jacbts.2017.08.005
_version_ 1783341794966110208
author Nordlohne, Johannes
Helmke, Alexandra
Ge, Shuwang
Rong, Song
Chen, Rongjun
Waisman, Ari
Haller, Hermann
von Vietinghoff, Sibylle
author_facet Nordlohne, Johannes
Helmke, Alexandra
Ge, Shuwang
Rong, Song
Chen, Rongjun
Waisman, Ari
Haller, Hermann
von Vietinghoff, Sibylle
author_sort Nordlohne, Johannes
collection PubMed
description Effective therapy of atherosclerotic complications in patients with chronic kidney disease (CKD) is an unmet clinical need. Cardiovascular events are the most common cause of death. At a glomerular filtration rate ≤60 ml/min, these events are increased also after correction for common risk factors. Previous studies have reported enhanced vascular inflammation in mice and recently also in humans. Our current data show, in a mouse model of atherosclerosis in moderate renal impairment, that interleukin-17 receptor A is instrumental in this condition, and blockade of this pathway can normalize arterial inflammation even in advanced atherosclerosis.
format Online
Article
Text
id pubmed-6058956
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-60589562018-07-30 Aggravated Atherosclerosis and Vascular Inflammation With Reduced Kidney Function Depend on Interleukin-17 Receptor A and Are Normalized by Inhibition of Interleukin-17A Nordlohne, Johannes Helmke, Alexandra Ge, Shuwang Rong, Song Chen, Rongjun Waisman, Ari Haller, Hermann von Vietinghoff, Sibylle JACC Basic Transl Sci PRECLINICAL RESEARCH Effective therapy of atherosclerotic complications in patients with chronic kidney disease (CKD) is an unmet clinical need. Cardiovascular events are the most common cause of death. At a glomerular filtration rate ≤60 ml/min, these events are increased also after correction for common risk factors. Previous studies have reported enhanced vascular inflammation in mice and recently also in humans. Our current data show, in a mouse model of atherosclerosis in moderate renal impairment, that interleukin-17 receptor A is instrumental in this condition, and blockade of this pathway can normalize arterial inflammation even in advanced atherosclerosis. Elsevier 2018-01-10 /pmc/articles/PMC6058956/ /pubmed/30062194 http://dx.doi.org/10.1016/j.jacbts.2017.08.005 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle PRECLINICAL RESEARCH
Nordlohne, Johannes
Helmke, Alexandra
Ge, Shuwang
Rong, Song
Chen, Rongjun
Waisman, Ari
Haller, Hermann
von Vietinghoff, Sibylle
Aggravated Atherosclerosis and Vascular Inflammation With Reduced Kidney Function Depend on Interleukin-17 Receptor A and Are Normalized by Inhibition of Interleukin-17A
title Aggravated Atherosclerosis and Vascular Inflammation With Reduced Kidney Function Depend on Interleukin-17 Receptor A and Are Normalized by Inhibition of Interleukin-17A
title_full Aggravated Atherosclerosis and Vascular Inflammation With Reduced Kidney Function Depend on Interleukin-17 Receptor A and Are Normalized by Inhibition of Interleukin-17A
title_fullStr Aggravated Atherosclerosis and Vascular Inflammation With Reduced Kidney Function Depend on Interleukin-17 Receptor A and Are Normalized by Inhibition of Interleukin-17A
title_full_unstemmed Aggravated Atherosclerosis and Vascular Inflammation With Reduced Kidney Function Depend on Interleukin-17 Receptor A and Are Normalized by Inhibition of Interleukin-17A
title_short Aggravated Atherosclerosis and Vascular Inflammation With Reduced Kidney Function Depend on Interleukin-17 Receptor A and Are Normalized by Inhibition of Interleukin-17A
title_sort aggravated atherosclerosis and vascular inflammation with reduced kidney function depend on interleukin-17 receptor a and are normalized by inhibition of interleukin-17a
topic PRECLINICAL RESEARCH
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058956/
https://www.ncbi.nlm.nih.gov/pubmed/30062194
http://dx.doi.org/10.1016/j.jacbts.2017.08.005
work_keys_str_mv AT nordlohnejohannes aggravatedatherosclerosisandvascularinflammationwithreducedkidneyfunctiondependoninterleukin17receptoraandarenormalizedbyinhibitionofinterleukin17a
AT helmkealexandra aggravatedatherosclerosisandvascularinflammationwithreducedkidneyfunctiondependoninterleukin17receptoraandarenormalizedbyinhibitionofinterleukin17a
AT geshuwang aggravatedatherosclerosisandvascularinflammationwithreducedkidneyfunctiondependoninterleukin17receptoraandarenormalizedbyinhibitionofinterleukin17a
AT rongsong aggravatedatherosclerosisandvascularinflammationwithreducedkidneyfunctiondependoninterleukin17receptoraandarenormalizedbyinhibitionofinterleukin17a
AT chenrongjun aggravatedatherosclerosisandvascularinflammationwithreducedkidneyfunctiondependoninterleukin17receptoraandarenormalizedbyinhibitionofinterleukin17a
AT waismanari aggravatedatherosclerosisandvascularinflammationwithreducedkidneyfunctiondependoninterleukin17receptoraandarenormalizedbyinhibitionofinterleukin17a
AT hallerhermann aggravatedatherosclerosisandvascularinflammationwithreducedkidneyfunctiondependoninterleukin17receptoraandarenormalizedbyinhibitionofinterleukin17a
AT vonvietinghoffsibylle aggravatedatherosclerosisandvascularinflammationwithreducedkidneyfunctiondependoninterleukin17receptoraandarenormalizedbyinhibitionofinterleukin17a

Ejemplares similares