Diabetes Exacerbates Myocardial Ischemia/Reperfusion Injury by Down-Regulation of MicroRNA and Up-Regulation of O-GlcNAcylation

Management for patients with diabetes experiencing myocardial infarction remains a challenge. Here the authors show that hyperglycemia- and hyperinsulinemia-induced microRNA-24 (miR-24) reduction and O-GlcNAcylation in the diabetic heart contribute to poor survival and increased infarct size in diab...

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Detalles Bibliográficos
Autores principales: Wang, Dandan, Hu, Xiaoyue, Lee, Seung Hee, Chen, Feng, Jiang, Kai, Tu, Zizhuo, Liu, Zejian, Du, Jing, Wang, Li, Yin, Chaoying, Liao, Yu, Shang, Hongcai, Martin, Kathleen A., Herzog, Raimund I., Young, Lawrence H., Qian, Li, Hwa, John, Xiang, Yaozu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
PRECLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058960/
https://www.ncbi.nlm.nih.gov/pubmed/30062222
http://dx.doi.org/10.1016/j.jacbts.2018.01.005

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