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Alterations in Titin Properties and Myocardial Fibrosis Correlate With Clinical Phenotypes in Hemodynamic Subgroups of Severe Aortic Stenosis

Titin-isoform expression, titin phosphorylation, and myocardial fibrosis were studied in 30 patients with severe symptomatic aortic stenosis (AS). Patients were grouped into “classical” high-gradient, normal-flow AS with preserved ejection fraction (EF); “paradoxical” low-flow, low-gradient AS with...

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Autores principales: Gotzmann, Michael, Grabbe, Susanne, Schöne, Dominik, von Frieling-Salewsky, Marion, dos Remedios, Cristobal G., Strauch, Justus, Bechtel, Matthias, Dietrich, Johannes W., Tannapfel, Andrea, Mügge, Andreas, Linke, Wolfgang A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6059007/
https://www.ncbi.nlm.nih.gov/pubmed/30062220
http://dx.doi.org/10.1016/j.jacbts.2018.02.002
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author Gotzmann, Michael
Grabbe, Susanne
Schöne, Dominik
von Frieling-Salewsky, Marion
dos Remedios, Cristobal G.
Strauch, Justus
Bechtel, Matthias
Dietrich, Johannes W.
Tannapfel, Andrea
Mügge, Andreas
Linke, Wolfgang A.
author_facet Gotzmann, Michael
Grabbe, Susanne
Schöne, Dominik
von Frieling-Salewsky, Marion
dos Remedios, Cristobal G.
Strauch, Justus
Bechtel, Matthias
Dietrich, Johannes W.
Tannapfel, Andrea
Mügge, Andreas
Linke, Wolfgang A.
author_sort Gotzmann, Michael
collection PubMed
description Titin-isoform expression, titin phosphorylation, and myocardial fibrosis were studied in 30 patients with severe symptomatic aortic stenosis (AS). Patients were grouped into “classical” high-gradient, normal-flow AS with preserved ejection fraction (EF); “paradoxical” low-flow, low-gradient AS with preserved EF; and AS with reduced EF. Nonfailing donor hearts served as controls. AS was associated with increased fibrosis, titin-isoform switch toward compliant N2BA, and both total and site-specific titin hypophosphorylation compared with control hearts. All AS subtypes revealed titin and matrix alterations. The extent of myocardial remodeling in “paradoxical” AS was no less severe than in other AS subtypes, thus explaining the unfavorable prognosis.
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spelling pubmed-60590072018-07-30 Alterations in Titin Properties and Myocardial Fibrosis Correlate With Clinical Phenotypes in Hemodynamic Subgroups of Severe Aortic Stenosis Gotzmann, Michael Grabbe, Susanne Schöne, Dominik von Frieling-Salewsky, Marion dos Remedios, Cristobal G. Strauch, Justus Bechtel, Matthias Dietrich, Johannes W. Tannapfel, Andrea Mügge, Andreas Linke, Wolfgang A. JACC Basic Transl Sci CLINICAL RESEARCH Titin-isoform expression, titin phosphorylation, and myocardial fibrosis were studied in 30 patients with severe symptomatic aortic stenosis (AS). Patients were grouped into “classical” high-gradient, normal-flow AS with preserved ejection fraction (EF); “paradoxical” low-flow, low-gradient AS with preserved EF; and AS with reduced EF. Nonfailing donor hearts served as controls. AS was associated with increased fibrosis, titin-isoform switch toward compliant N2BA, and both total and site-specific titin hypophosphorylation compared with control hearts. All AS subtypes revealed titin and matrix alterations. The extent of myocardial remodeling in “paradoxical” AS was no less severe than in other AS subtypes, thus explaining the unfavorable prognosis. Elsevier 2018-06-25 /pmc/articles/PMC6059007/ /pubmed/30062220 http://dx.doi.org/10.1016/j.jacbts.2018.02.002 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle CLINICAL RESEARCH
Gotzmann, Michael
Grabbe, Susanne
Schöne, Dominik
von Frieling-Salewsky, Marion
dos Remedios, Cristobal G.
Strauch, Justus
Bechtel, Matthias
Dietrich, Johannes W.
Tannapfel, Andrea
Mügge, Andreas
Linke, Wolfgang A.
Alterations in Titin Properties and Myocardial Fibrosis Correlate With Clinical Phenotypes in Hemodynamic Subgroups of Severe Aortic Stenosis
title Alterations in Titin Properties and Myocardial Fibrosis Correlate With Clinical Phenotypes in Hemodynamic Subgroups of Severe Aortic Stenosis
title_full Alterations in Titin Properties and Myocardial Fibrosis Correlate With Clinical Phenotypes in Hemodynamic Subgroups of Severe Aortic Stenosis
title_fullStr Alterations in Titin Properties and Myocardial Fibrosis Correlate With Clinical Phenotypes in Hemodynamic Subgroups of Severe Aortic Stenosis
title_full_unstemmed Alterations in Titin Properties and Myocardial Fibrosis Correlate With Clinical Phenotypes in Hemodynamic Subgroups of Severe Aortic Stenosis
title_short Alterations in Titin Properties and Myocardial Fibrosis Correlate With Clinical Phenotypes in Hemodynamic Subgroups of Severe Aortic Stenosis
title_sort alterations in titin properties and myocardial fibrosis correlate with clinical phenotypes in hemodynamic subgroups of severe aortic stenosis
topic CLINICAL RESEARCH
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6059007/
https://www.ncbi.nlm.nih.gov/pubmed/30062220
http://dx.doi.org/10.1016/j.jacbts.2018.02.002
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