Alterations in Titin Properties and Myocardial Fibrosis Correlate With Clinical Phenotypes in Hemodynamic Subgroups of Severe Aortic Stenosis

Titin-isoform expression, titin phosphorylation, and myocardial fibrosis were studied in 30 patients with severe symptomatic aortic stenosis (AS). Patients were grouped into “classical” high-gradient, normal-flow AS with preserved ejection fraction (EF); “paradoxical” low-flow, low-gradient AS with...

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Detalles Bibliográficos
Autores principales: Gotzmann, Michael, Grabbe, Susanne, Schöne, Dominik, von Frieling-Salewsky, Marion, dos Remedios, Cristobal G., Strauch, Justus, Bechtel, Matthias, Dietrich, Johannes W., Tannapfel, Andrea, Mügge, Andreas, Linke, Wolfgang A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
CLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6059007/
https://www.ncbi.nlm.nih.gov/pubmed/30062220
http://dx.doi.org/10.1016/j.jacbts.2018.02.002

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