Cargando…

A Morpholino Oligomer Therapy Regime That Restores Mitochondrial Function and Prevents mdx Cardiomyopathy

Current clinical trials demonstrate Duchenne muscular dystrophy (DMD) patients receiving phosphorodiamidate morpholino oligomer (PMO) therapy exhibit improved ambulation and stable pulmonary function; however, cardiac abnormalities remain. Utilizing the same PMO chemistry as current clinical trials,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Viola, Helena M., Johnstone, Victoria P.A., Adams, Abbie M., Fletcher, Susan, Hool, Livia C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2018
Materias:	PRECLINICAL RESEARCH
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6059013/ https://www.ncbi.nlm.nih.gov/pubmed/30062225 http://dx.doi.org/10.1016/j.jacbts.2018.03.007

Ejemplares similares

Morpholino Oligomer-Induced Dystrophin Isoforms to Map the Functional Domains in the Dystrophin Protein
por: Li, Dunhui, et al.
Publicado: (2020)

Long-Term Morpholino Oligomers in Hexose Elicits Long-Lasting Therapeutic Improvements in mdx Mice
por: Han, Gang, et al.
Publicado: (2018)

Long-Term Morpholino Oligomers in Hexose Elicit Long-Lasting Therapeutic Improvements in mdx Mice
por: Han, Gang, et al.
Publicado: (2020)

Pharmacokinetic/Pharmacodynamic Modeling of a Cell-Penetrating Peptide Phosphorodiamidate Morpholino Oligomer in mdx Mice
por: Mukashyaka, Marie Claire, et al.
Publicado: (2021)

A cell-penetrating peptide enhances delivery and efficacy of phosphorodiamidate morpholino oligomers in mdx mice
por: Gan, Li, et al.
Publicado: (2022)

In Vitro Validation of Phosphorodiamidate Morpholino Oligomers
por: Aung-Htut, May T., et al.
Publicado: (2019)

Dystrophic Cardiomyopathy—Potential Role of Calcium in Pathogenesis, Treatment and Novel Therapies
por: Johnstone, Victoria P. A., et al.
Publicado: (2017)

Tween 85-Modified Low Molecular Weight PEI Enhances Exon-Skipping of Antisense Morpholino Oligomer In Vitro and in mdx Mice
por: Wang, Mingxing, et al.
Publicado: (2017)

Effective Dystrophin Restoration by a Novel Muscle-Homing Peptide-Morpholino Conjugate in Dystrophin-Deficient mdx Mice
por: Gao, Xianjun, et al.
Publicado: (2020)

Aminoglycoside Enhances the Delivery of Antisense Morpholino Oligonucleotides In Vitro and in mdx Mice
por: Wang, Mingxing, et al.
Publicado: (2019)

Preventative therapeutic approaches for hypertrophic cardiomyopathy
por: Solomon, Tanya, et al.
Publicado: (2020)

Antisense Phosphorodiamidate Morpholino Oligomers as Novel Antiviral Compounds
por: Nan, Yuchen, et al.
Publicado: (2018)

Saponins as Natural Adjuvant for Antisense Morpholino Oligonucleotides Delivery In Vitro and in mdx Mice
por: Wang, Mingxing, et al.
Publicado: (2018)

Polyquaternium-mediated delivery of morpholino oligonucleotides for exon-skipping in vitro and in mdx mice
por: Wang, Mingxing, et al.
Publicado: (2017)

MCR-1 Inhibition with Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers Restores Sensitivity to Polymyxin in Escherichia coli
por: Daly, Seth M., et al.
Publicado: (2017)

Inhibition of norovirus replication by morpholino oligomers targeting the 5′-end of the genome
por: Bok, Karin, et al.
Publicado: (2008)

Characterization and validation of a preventative therapy for hypertrophic cardiomyopathy in a murine model of the disease
por: Viola, Helena M., et al.
Publicado: (2020)

Evaluation of Amphiphilic Peptide Modified Antisense Morpholino Oligonucleotides In Vitro and in Dystrophic mdx Mice
por: Wang, Mingxing, et al.
Publicado: (2017)

Advanced morpholino oligomers: A novel approach to antiviral therapy
por: Warren, Travis K., et al.
Publicado: (2012)

Long-term blinded placebo-controlled study of SNT-MC17/idebenone in the dystrophin deficient mdx mouse: cardiac protection and improved exercise performance
por: Buyse, Gunnar M., et al.
Publicado: (2009)

The Role of the L-Type Ca(2+) Channel in Altered Metabolic Activity in a Murine Model of Hypertrophic Cardiomyopathy
por: Viola, Helena M., et al.
Publicado: (2016)

Cationic polyelectrolyte-mediated delivery of antisense morpholino oligonucleotides for exon-skipping in vitro and in mdx mice
por: Wang, Mingxing, et al.
Publicado: (2015)

Inhibition of alphavirus infection in cell culture and in mice with antisense morpholino oligomers
por: Paessler, Slobodan, et al.
Publicado: (2008)

Inhibition of KSHV-associated lymphoma engraftment in SCID mouse by morpholino oligomers
por: Nan, Yuchen, et al.
Publicado: (2010)

Manipulation of gene expression in zebrafish using caged circular morpholino oligomers
por: Wang, Yuan, et al.
Publicado: (2012)

Inhibition and Escape of SARS-CoV Treated with Antisense Morpholino Oligomers
por: Neuman, Benjamin W., et al.
Publicado: (2006)

Fully automated fast-flow synthesis of antisense phosphorodiamidate morpholino oligomers
por: Li, Chengxi, et al.
Publicado: (2021)

Antiviral and Neuroprotective Role of Octaguanidinium Dendrimer-Conjugated Morpholino Oligomers in Japanese Encephalitis
por: Nazmi, Arshed, et al.
Publicado: (2010)

Suppression of porcine reproductive and respiratory syndrome virus replication by morpholino antisense oligomers
por: Zhang, Yan-Jin, et al.
Publicado: (2006)

Inhibition of enterovirus 71 infection by antisense octaguanidinium dendrimer-conjugated morpholino oligomers
por: Tan, Chee Wah, et al.
Publicado: (2014)

MOTS‐c promotes phosphorodiamidate morpholino oligomer uptake and efficacy in dystrophic mice
por: Ran, Ning, et al.
Publicado: (2020)

Cell-Penetrating d-Peptides Retain Antisense Morpholino Oligomer Delivery Activity
por: Schissel, Carly K., et al.
Publicado: (2022)

The use of urinary and kidney SILAM proteomics to monitor kidney response to high dose morpholino oligonucleotides in the mdx mouse
por: Zhang, Aiping, et al.
Publicado: (2015)

Gene-Specific Countermeasures against Ebola Virus Based on Antisense Phosphorodiamidate Morpholino Oligomers
por: Warfield, Kelly L, et al.
Publicado: (2006)

Peptide-conjugated morpholino oligomers inhibit porcine reproductive and respiratory syndrome virus replication
por: Patel, Deendayal, et al.
Publicado: (2008)

Enhanced inhibition of porcine reproductive and respiratory syndrome virus replication by combination of morpholino oligomers
por: Han, Xue, et al.
Publicado: (2009)

Practical Synthesis of Quinoline-Protected Morpholino Oligomers for Light-Triggered Regulation of Gene Function
por: Deodato, Davide, et al.
Publicado: (2020)

Development of Novel Bioanalytical Methods to Determine the Effective Concentrations of Phosphorodiamidate Morpholino Oligomers in Tissues and Cells
por: Schnell, Frederick J., et al.
Publicado: (2013)

Characterization of the Myocardial Inflammatory Response in Acute Stress-Induced (Takotsubo) Cardiomyopathy
por: Wilson, Heather M., et al.
Publicado: (2018)

Induction of revertant fibres in the mdx mouse using antisense oligonucleotides
por: Fall, Abbie M, et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_e4t75u20crp2fd1dn2d184abhu