Transplantation of Allogeneic PW1(pos)/Pax7(neg) Interstitial Cells Enhance Endogenous Repair of Injured Porcine Skeletal Muscle

Skeletal muscle-derived PW1(pos)/Pax7(neg) interstitial cells (PICs) express and secrete a multitude of proregenerative growth factors and cytokines. Utilizing a porcine preclinical skeletal muscle injury model, delivery of allogeneic porcine PICs (pPICs) significantly improved and accelerated myofi...

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Detalles Bibliográficos
Autores principales: Lewis, Fiona C., Cottle, Beverley J., Shone, Victoria, Marazzi, Giovanna, Sassoon, David, Tseng, Cheyenne C.S., Dankers, Patricia Y.W., Chamuleau, Steven A.J., Nadal-Ginard, Bernardo, Ellison-Hughes, Georgina M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
PRECLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6059014/
https://www.ncbi.nlm.nih.gov/pubmed/30062184
http://dx.doi.org/10.1016/j.jacbts.2017.08.002
Descripción
Sumario:Skeletal muscle-derived PW1(pos)/Pax7(neg) interstitial cells (PICs) express and secrete a multitude of proregenerative growth factors and cytokines. Utilizing a porcine preclinical skeletal muscle injury model, delivery of allogeneic porcine PICs (pPICs) significantly improved and accelerated myofiber regeneration and neocapillarization, compared with saline vehicle control-treated muscles. Allogeneic pPICs did not contribute to new myofibers or capillaries and were eliminated by the host immune system. In conclusion, allogeneic pPIC transplantation stimulated the endogenous stem cell pool to bring about enhanced autologous skeletal muscle repair and regeneration. This allogeneic cell approach is considered a cost-effective, easy to apply, and readily available regenerative therapeutic strategy.

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