Transplantation of Allogeneic PW1(pos)/Pax7(neg) Interstitial Cells Enhance Endogenous Repair of Injured Porcine Skeletal Muscle

Skeletal muscle-derived PW1(pos)/Pax7(neg) interstitial cells (PICs) express and secrete a multitude of proregenerative growth factors and cytokines. Utilizing a porcine preclinical skeletal muscle injury model, delivery of allogeneic porcine PICs (pPICs) significantly improved and accelerated myofi...

Descripción completa

Detalles Bibliográficos
Autores principales: Lewis, Fiona C., Cottle, Beverley J., Shone, Victoria, Marazzi, Giovanna, Sassoon, David, Tseng, Cheyenne C.S., Dankers, Patricia Y.W., Chamuleau, Steven A.J., Nadal-Ginard, Bernardo, Ellison-Hughes, Georgina M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
PRECLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6059014/
https://www.ncbi.nlm.nih.gov/pubmed/30062184
http://dx.doi.org/10.1016/j.jacbts.2017.08.002
_version_ 1783341801035268096
author Lewis, Fiona C.
Cottle, Beverley J.
Shone, Victoria
Marazzi, Giovanna
Sassoon, David
Tseng, Cheyenne C.S.
Dankers, Patricia Y.W.
Chamuleau, Steven A.J.
Nadal-Ginard, Bernardo
Ellison-Hughes, Georgina M.
author_facet Lewis, Fiona C.
Cottle, Beverley J.
Shone, Victoria
Marazzi, Giovanna
Sassoon, David
Tseng, Cheyenne C.S.
Dankers, Patricia Y.W.
Chamuleau, Steven A.J.
Nadal-Ginard, Bernardo
Ellison-Hughes, Georgina M.
author_sort Lewis, Fiona C.
collection PubMed
description Skeletal muscle-derived PW1(pos)/Pax7(neg) interstitial cells (PICs) express and secrete a multitude of proregenerative growth factors and cytokines. Utilizing a porcine preclinical skeletal muscle injury model, delivery of allogeneic porcine PICs (pPICs) significantly improved and accelerated myofiber regeneration and neocapillarization, compared with saline vehicle control-treated muscles. Allogeneic pPICs did not contribute to new myofibers or capillaries and were eliminated by the host immune system. In conclusion, allogeneic pPIC transplantation stimulated the endogenous stem cell pool to bring about enhanced autologous skeletal muscle repair and regeneration. This allogeneic cell approach is considered a cost-effective, easy to apply, and readily available regenerative therapeutic strategy.
format Online
Article
Text
id pubmed-6059014
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-60590142018-07-30 Transplantation of Allogeneic PW1(pos)/Pax7(neg) Interstitial Cells Enhance Endogenous Repair of Injured Porcine Skeletal Muscle Lewis, Fiona C. Cottle, Beverley J. Shone, Victoria Marazzi, Giovanna Sassoon, David Tseng, Cheyenne C.S. Dankers, Patricia Y.W. Chamuleau, Steven A.J. Nadal-Ginard, Bernardo Ellison-Hughes, Georgina M. JACC Basic Transl Sci PRECLINICAL RESEARCH Skeletal muscle-derived PW1(pos)/Pax7(neg) interstitial cells (PICs) express and secrete a multitude of proregenerative growth factors and cytokines. Utilizing a porcine preclinical skeletal muscle injury model, delivery of allogeneic porcine PICs (pPICs) significantly improved and accelerated myofiber regeneration and neocapillarization, compared with saline vehicle control-treated muscles. Allogeneic pPICs did not contribute to new myofibers or capillaries and were eliminated by the host immune system. In conclusion, allogeneic pPIC transplantation stimulated the endogenous stem cell pool to bring about enhanced autologous skeletal muscle repair and regeneration. This allogeneic cell approach is considered a cost-effective, easy to apply, and readily available regenerative therapeutic strategy. Elsevier 2017-12-13 /pmc/articles/PMC6059014/ /pubmed/30062184 http://dx.doi.org/10.1016/j.jacbts.2017.08.002 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle PRECLINICAL RESEARCH
Lewis, Fiona C.
Cottle, Beverley J.
Shone, Victoria
Marazzi, Giovanna
Sassoon, David
Tseng, Cheyenne C.S.
Dankers, Patricia Y.W.
Chamuleau, Steven A.J.
Nadal-Ginard, Bernardo
Ellison-Hughes, Georgina M.
Transplantation of Allogeneic PW1(pos)/Pax7(neg) Interstitial Cells Enhance Endogenous Repair of Injured Porcine Skeletal Muscle
title Transplantation of Allogeneic PW1(pos)/Pax7(neg) Interstitial Cells Enhance Endogenous Repair of Injured Porcine Skeletal Muscle
title_full Transplantation of Allogeneic PW1(pos)/Pax7(neg) Interstitial Cells Enhance Endogenous Repair of Injured Porcine Skeletal Muscle
title_fullStr Transplantation of Allogeneic PW1(pos)/Pax7(neg) Interstitial Cells Enhance Endogenous Repair of Injured Porcine Skeletal Muscle
title_full_unstemmed Transplantation of Allogeneic PW1(pos)/Pax7(neg) Interstitial Cells Enhance Endogenous Repair of Injured Porcine Skeletal Muscle
title_short Transplantation of Allogeneic PW1(pos)/Pax7(neg) Interstitial Cells Enhance Endogenous Repair of Injured Porcine Skeletal Muscle
title_sort transplantation of allogeneic pw1(pos)/pax7(neg) interstitial cells enhance endogenous repair of injured porcine skeletal muscle
topic PRECLINICAL RESEARCH
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6059014/
https://www.ncbi.nlm.nih.gov/pubmed/30062184
http://dx.doi.org/10.1016/j.jacbts.2017.08.002
work_keys_str_mv AT lewisfionac transplantationofallogeneicpw1pospax7neginterstitialcellsenhanceendogenousrepairofinjuredporcineskeletalmuscle
AT cottlebeverleyj transplantationofallogeneicpw1pospax7neginterstitialcellsenhanceendogenousrepairofinjuredporcineskeletalmuscle
AT shonevictoria transplantationofallogeneicpw1pospax7neginterstitialcellsenhanceendogenousrepairofinjuredporcineskeletalmuscle
AT marazzigiovanna transplantationofallogeneicpw1pospax7neginterstitialcellsenhanceendogenousrepairofinjuredporcineskeletalmuscle
AT sassoondavid transplantationofallogeneicpw1pospax7neginterstitialcellsenhanceendogenousrepairofinjuredporcineskeletalmuscle
AT tsengcheyennecs transplantationofallogeneicpw1pospax7neginterstitialcellsenhanceendogenousrepairofinjuredporcineskeletalmuscle
AT dankerspatriciayw transplantationofallogeneicpw1pospax7neginterstitialcellsenhanceendogenousrepairofinjuredporcineskeletalmuscle
AT chamuleaustevenaj transplantationofallogeneicpw1pospax7neginterstitialcellsenhanceendogenousrepairofinjuredporcineskeletalmuscle
AT nadalginardbernardo transplantationofallogeneicpw1pospax7neginterstitialcellsenhanceendogenousrepairofinjuredporcineskeletalmuscle
AT ellisonhughesgeorginam transplantationofallogeneicpw1pospax7neginterstitialcellsenhanceendogenousrepairofinjuredporcineskeletalmuscle

Ejemplares similares