Clonal heterogeneity of FLT3-ITD detected by high-throughput amplicon sequencing correlates with adverse prognosis in acute myeloid leukemia

In acute myeloid leukemia (AML), internal tandem duplications (ITDs) of FLT3 are frequent mutations associated with unfavorable prognosis. At diagnosis, the FLT3-ITD status is routinely assessed by fragment analysis, providing information about the length but not the position and sequence of the ITD...

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Detalles Bibliográficos
Autores principales: Schranz, Katrin, Hubmann, Max, Harin, Egor, Vosberg, Sebastian, Herold, Tobias, Metzeler, Klaus H., Rothenberg-Thurley, Maja, Janke, Hanna, Bräundl, Kathrin, Ksienzyk, Bianka, Batcha, Aarif M.N., Schaaf, Sebastian, Schneider, Stephanie, Bohlander, Stefan K., Görlich, Dennis, Berdel, Wolfgang E., Wörmann, Bernhard J., Braess, Jan, Krebs, Stefan, Hiddemann, Wolfgang, Mansmann, Ulrich, Spiekermann, Karsten, Greif, Philipp A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6059024/
https://www.ncbi.nlm.nih.gov/pubmed/30046393
http://dx.doi.org/10.18632/oncotarget.25729

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