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Chemical diversity from the Tibetan Plateau fungi Penicillium kongii and P. brasilianum
Two new secondary metabolites, kongiilines A and B (1, 7), and two asperphenamate derivatives, asperphenamates B and C (5–6), together with 16 known compounds (2–4, 8–20), were isolated from Tibetan Plateau fungi Penicillium kongii and Penicillium brasilianum. This is the first report on asperphenam...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6059045/ https://www.ncbi.nlm.nih.gov/pubmed/30123656 http://dx.doi.org/10.1080/21501203.2017.1331937 |
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author | Liu, Zhi-Guo Bao, Li Liu, Hong-Wei Ren, Jin-Wei Wang, Wen-Zhao Wang, Long Li, Wei Yin, Wen-Bing |
author_facet | Liu, Zhi-Guo Bao, Li Liu, Hong-Wei Ren, Jin-Wei Wang, Wen-Zhao Wang, Long Li, Wei Yin, Wen-Bing |
author_sort | Liu, Zhi-Guo |
collection | PubMed |
description | Two new secondary metabolites, kongiilines A and B (1, 7), and two asperphenamate derivatives, asperphenamates B and C (5–6), together with 16 known compounds (2–4, 8–20), were isolated from Tibetan Plateau fungi Penicillium kongii and Penicillium brasilianum. This is the first report on asperphenamates B and C as naturally occurring compounds, and that aspterric acid is isolated from P. brasilianum for the first time. Their structures were elucidated by different spectroscopic techniques including high-resolution electrospray ionisation mass spectrum, 1D nuclear magnetic resonance (NMR), and 2D NMR as well as electronic circular dichroism. Compounds 4, 5, and 10 exhibited cytotoxicity activities against human colon carcinoma HCT116 cell line with IC(50) values of 88.16, 77.68, and 36.92 μM, respectively. Fungi from Tibetan Plateau represent important and rich resources for the investigation of new chemicals. |
format | Online Article Text |
id | pubmed-6059045 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-60590452018-08-17 Chemical diversity from the Tibetan Plateau fungi Penicillium kongii and P. brasilianum Liu, Zhi-Guo Bao, Li Liu, Hong-Wei Ren, Jin-Wei Wang, Wen-Zhao Wang, Long Li, Wei Yin, Wen-Bing Mycology Article Two new secondary metabolites, kongiilines A and B (1, 7), and two asperphenamate derivatives, asperphenamates B and C (5–6), together with 16 known compounds (2–4, 8–20), were isolated from Tibetan Plateau fungi Penicillium kongii and Penicillium brasilianum. This is the first report on asperphenamates B and C as naturally occurring compounds, and that aspterric acid is isolated from P. brasilianum for the first time. Their structures were elucidated by different spectroscopic techniques including high-resolution electrospray ionisation mass spectrum, 1D nuclear magnetic resonance (NMR), and 2D NMR as well as electronic circular dichroism. Compounds 4, 5, and 10 exhibited cytotoxicity activities against human colon carcinoma HCT116 cell line with IC(50) values of 88.16, 77.68, and 36.92 μM, respectively. Fungi from Tibetan Plateau represent important and rich resources for the investigation of new chemicals. Taylor & Francis 2017-06-12 /pmc/articles/PMC6059045/ /pubmed/30123656 http://dx.doi.org/10.1080/21501203.2017.1331937 Text en © 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Article Liu, Zhi-Guo Bao, Li Liu, Hong-Wei Ren, Jin-Wei Wang, Wen-Zhao Wang, Long Li, Wei Yin, Wen-Bing Chemical diversity from the Tibetan Plateau fungi Penicillium kongii and P. brasilianum |
title | Chemical diversity from the Tibetan Plateau fungi Penicillium kongii and P. brasilianum |
title_full | Chemical diversity from the Tibetan Plateau fungi Penicillium kongii and P. brasilianum |
title_fullStr | Chemical diversity from the Tibetan Plateau fungi Penicillium kongii and P. brasilianum |
title_full_unstemmed | Chemical diversity from the Tibetan Plateau fungi Penicillium kongii and P. brasilianum |
title_short | Chemical diversity from the Tibetan Plateau fungi Penicillium kongii and P. brasilianum |
title_sort | chemical diversity from the tibetan plateau fungi penicillium kongii and p. brasilianum |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6059045/ https://www.ncbi.nlm.nih.gov/pubmed/30123656 http://dx.doi.org/10.1080/21501203.2017.1331937 |
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