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Beauveria bassiana: a new N(6)-(2-hydroxyethyl)-adenosine–producing fungus

N(6)-(2-Hydroxyethyl)-adenosine (HEA), which was the first calcium antagonist derived from biological sources, has been intensively investigated because of its ability to inhibit tumour cell proliferation, restrain inflammation, protect kidneys and function as a sedative and insecticide. Up to now,...

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Detalles Bibliográficos
Autores principales: Liu, Kuanbo, Wang, Fen, Wang, Wenzhao, Dong, Caihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6059059/
https://www.ncbi.nlm.nih.gov/pubmed/30123645
http://dx.doi.org/10.1080/21501203.2017.1375040
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author Liu, Kuanbo
Wang, Fen
Wang, Wenzhao
Dong, Caihong
author_facet Liu, Kuanbo
Wang, Fen
Wang, Wenzhao
Dong, Caihong
author_sort Liu, Kuanbo
collection PubMed
description N(6)-(2-Hydroxyethyl)-adenosine (HEA), which was the first calcium antagonist derived from biological sources, has been intensively investigated because of its ability to inhibit tumour cell proliferation, restrain inflammation, protect kidneys and function as a sedative and insecticide. Up to now, the production of HEA has been detected only in a few species such as Cordyceps pruinosa, C. militaris and Isaria tenuipes. Here, we found a new HEA-producing fungus, which was identified as Beauveria bassiana based on morphological and phylogenetic characteristics. The HEA production was verified by reversed-phase high-performance liquid chromatography/mass spectrometry in this fungus. Moreover, HEA was also detected in the mycelia of two other B. bassiana strains from different origins, but not in the culture medium of all tested B. bassiana strains. The maximum production of HEA (0.8483 ± 0.0439 mg/g mycelia dry weight) was achieved on day 7. The fungal biomass and kinetics of HEA production exhibited similar trends over the duration of the culture period. This is the first report describing HEA production in B. bassiana, which suggests that this fungal strain may have new applications as a source of HEA.
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spelling pubmed-60590592018-08-17 Beauveria bassiana: a new N(6)-(2-hydroxyethyl)-adenosine–producing fungus Liu, Kuanbo Wang, Fen Wang, Wenzhao Dong, Caihong Mycology Article N(6)-(2-Hydroxyethyl)-adenosine (HEA), which was the first calcium antagonist derived from biological sources, has been intensively investigated because of its ability to inhibit tumour cell proliferation, restrain inflammation, protect kidneys and function as a sedative and insecticide. Up to now, the production of HEA has been detected only in a few species such as Cordyceps pruinosa, C. militaris and Isaria tenuipes. Here, we found a new HEA-producing fungus, which was identified as Beauveria bassiana based on morphological and phylogenetic characteristics. The HEA production was verified by reversed-phase high-performance liquid chromatography/mass spectrometry in this fungus. Moreover, HEA was also detected in the mycelia of two other B. bassiana strains from different origins, but not in the culture medium of all tested B. bassiana strains. The maximum production of HEA (0.8483 ± 0.0439 mg/g mycelia dry weight) was achieved on day 7. The fungal biomass and kinetics of HEA production exhibited similar trends over the duration of the culture period. This is the first report describing HEA production in B. bassiana, which suggests that this fungal strain may have new applications as a source of HEA. Taylor & Francis 2017-09-11 /pmc/articles/PMC6059059/ /pubmed/30123645 http://dx.doi.org/10.1080/21501203.2017.1375040 Text en © 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Liu, Kuanbo
Wang, Fen
Wang, Wenzhao
Dong, Caihong
Beauveria bassiana: a new N(6)-(2-hydroxyethyl)-adenosine–producing fungus
title Beauveria bassiana: a new N(6)-(2-hydroxyethyl)-adenosine–producing fungus
title_full Beauveria bassiana: a new N(6)-(2-hydroxyethyl)-adenosine–producing fungus
title_fullStr Beauveria bassiana: a new N(6)-(2-hydroxyethyl)-adenosine–producing fungus
title_full_unstemmed Beauveria bassiana: a new N(6)-(2-hydroxyethyl)-adenosine–producing fungus
title_short Beauveria bassiana: a new N(6)-(2-hydroxyethyl)-adenosine–producing fungus
title_sort beauveria bassiana: a new n(6)-(2-hydroxyethyl)-adenosine–producing fungus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6059059/
https://www.ncbi.nlm.nih.gov/pubmed/30123645
http://dx.doi.org/10.1080/21501203.2017.1375040
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