Cargando…

Uncertainty quantification in ToxCast high throughput screening

High throughput screening (HTS) projects like the U.S. Environmental Protection Agency's ToxCast program are required to address the large and rapidly increasing number of chemicals for which we have little to no toxicity measurements. Concentration-response parameters such as potency and effic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Watt, Eric D., Judson, Richard S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6059398/ https://www.ncbi.nlm.nih.gov/pubmed/30044784 http://dx.doi.org/10.1371/journal.pone.0196963

Ejemplares similares

Comment on “On the Utility of ToxCast™ and ToxPi as Methods for Identifying New Obesogens”
por: Houck, Keith A., et al.
Publicado: (2017)

In Vitro Screening of Environmental Chemicals for Targeted Testing Prioritization: The ToxCast Project
por: Judson, Richard S., et al.
Publicado: (2010)

Endocrine Profiling and Prioritization of Environmental Chemicals Using ToxCast Data
por: Reif, David M., et al.
Publicado: (2010)

On the Utility of ToxCast™ and ToxPi as Methods for Identifying New Obesogens
por: Janesick, Amanda Shaine, et al.
Publicado: (2016)

Prioritizing Environmental Chemicals for Obesity and Diabetes Outcomes Research: A Screening Approach Using ToxCast™ High-Throughput Data
por: Auerbach, Scott, et al.
Publicado: (2016)

The ToxCast pipeline: updates to curve-fitting approaches and database structure
por: Feshuk, M., et al.
Publicado: (2023)

Profiling 976 ToxCast Chemicals across 331 Enzymatic and Receptor Signaling Assays
por: Sipes, Nisha S., et al.
Publicado: (2013)

Potential of ToxCast Data in the Safety Assessment of Food Chemicals
por: Punt, Ans, et al.
Publicado: (2020)

Reply to “Comment on ‘On the Utility of ToxCast™ and ToxPi as Methods for Identifying New Obesogens’”
por: Janesick, Amanda S., et al.
Publicado: (2017)

ToxCast on Target: In Vitro Assays and Computer Modeling Show Promise for Screening Chemicals
por: Haynes, Rebecca Clay
Publicado: (2010)

ToxCast(™) Wants You: Recommendations for Engaging the Broader Scientific Community
por: Arnold, Carrie
Publicado: (2015)

ToxCast chemical library Wnt screen identifies diethanolamine as an activator of neural progenitor proliferation
por: Wolter, Justin M., et al.
Publicado: (2022)

Using ToxCast™ Data to Reconstruct Dynamic Cell State Trajectories and Estimate Toxicological Points of Departure
por: Shah, Imran, et al.
Publicado: (2015)

High-throughput screening and chemotype-enrichment analysis of ToxCast phase II chemicals evaluated for human sodium-iodide symporter (NIS) inhibition
por: Wang, Jun, et al.
Publicado: (2019)

Investigating Molecular Mechanisms of Immunotoxicity and the Utility of ToxCast for Immunotoxicity Screening of Chemicals Added to Food
por: Naidenko, Olga V., et al.
Publicado: (2021)

Evaluation of Computational Docking to Identify Pregnane X Receptor Agonists in the ToxCast Database
por: Kortagere, Sandhya, et al.
Publicado: (2010)

ToxCast EPA in Vitro to in Vivo Challenge: Insight into the Rank-I Model
por: Novotarskyi, Sergii, et al.
Publicado: (2016)

On the Utility of ToxCast-Based Predictive Models to Evaluate Potential Metabolic Disruption by Environmental Chemicals
por: Filer, Dayne L., et al.
Publicado: (2022)

QSAR modeling for In vitro assays: linking ToxCast™ database to the integrated modeling framework “OCHEM”
por: Abdelaziz, Ahmed, et al.
Publicado: (2012)

Informing Selection of Nanomaterial Concentrations for ToxCast in Vitro Testing Based on Occupational Exposure Potential
por: Gangwal, Sumit, et al.
Publicado: (2011)

Screening ToxCast™ for Chemicals That Affect Cholesterol Biosynthesis: Studies in Cell Culture and Human Induced Pluripotent Stem Cell–Derived Neuroprogenitors
por: Wages, Phillip A., et al.
Publicado: (2020)

Editor’s Highlight: Screening ToxCast Prioritized Chemicals for PPARG Function in a Human Adipose-Derived Stem Cell Model of Adipogenesis
por: Foley, Briana, et al.
Publicado: (2017)

Evaluation of OASIS QSAR Models Using ToxCast™ in Vitro Estrogen and Androgen Receptor Binding Data and Application in an Integrated Endocrine Screening Approach
por: Bhhatarai, Barun, et al.
Publicado: (2016)

Comparison between endocrine activity assessed using ToxCast/Tox21 database and human plasma concentration of sunscreen active ingredients/UV filters
por: Onyango, David O, et al.
Publicado: (2023)

Developmental Effects of the ToxCast™ Phase I and Phase II Chemicals in Caenorhabditis elegans and Corresponding Responses in Zebrafish, Rats, and Rabbits
por: Boyd, Windy A., et al.
Publicado: (2015)

In silico identification of protein targets for chemical neurotoxins using ToxCast in vitro data and read-across within the QSAR toolbox
por: Chushak, Y. G., et al.
Publicado: (2018)

Analysis of structure–activity and structure–mechanism relationships among thyroid stimulating hormone receptor binding chemicals by leveraging the ToxCast library
por: Sahoo, Ajaya Kumar, et al.
Publicado: (2023)

Derivation of a Human In Vivo Benchmark Dose for Bisphenol A from ToxCast In Vitro Concentration Response Data Using a Computational Workflow for Probabilistic Quantitative In Vitro to In Vivo Extrapolation
por: Loizou, George, et al.
Publicado: (2022)

Derivation of a Human In Vivo Benchmark Dose for Perfluorooctanoic Acid From ToxCast In Vitro Concentration–Response Data Using a Computational Workflow for Probabilistic Quantitative In Vitro to In Vivo Extrapolation
por: Loizou, George, et al.
Publicado: (2021)

Using Tox21 High-Throughput Screening Assays for the Evaluation of Botanical and Dietary Supplements
por: Hubbard, Troy D., et al.
Publicado: (2019)

TriTOX: A novel Trichomonas vaginalis assay platform for high-throughput screening of compound libraries
por: Lam, Alexander Y.F., et al.
Publicado: (2021)

Bioactivity Signatures of Drugs vs. Environmental Chemicals Revealed by Tox21 High-Throughput Screening Assays
por: Ngan, Deborah K., et al.
Publicado: (2019)

High-Throughput Screening to Predict Chemical-Assay Interference
por: Borrel, Alexandre, et al.
Publicado: (2020)

Profiling Chemicals Based on Chronic Toxicity Results from the U.S. EPA ToxRef Database
por: Martin, Matthew T., et al.
Publicado: (2009)

Uncertainty quantification
por: Chase, Luis
Publicado: (2019)

Environmental Impact on Vascular Development Predicted by High-Throughput Screening
por: Kleinstreuer, Nicole C., et al.
Publicado: (2011)

The periplasmic domains of Vibriocholerae ToxR and ToxS are forming a strong heterodimeric complex independent on the redox state of ToxR cysteines
por: Gubensäk, Nina, et al.
Publicado: (2021)

The CompTox Chemistry Dashboard: a community data resource for environmental chemistry
por: Williams, Antony J., et al.
Publicado: (2017)

Atomistic Analysis of ToxN and ToxI Complex Unbinding Mechanism
por: Hu, Guodong, et al.
Publicado: (2018)

Uncertainty Quantification of Reactivity Scales
por: Proppe, Jonny, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_62e9afs0qit6javcgeaaehh0se