Automated size selection for short cell-free DNA fragments enriches for circulating tumor DNA and improves error correction during next generation sequencing

Circulating tumor-derived cell-free DNA (ctDNA) enables non-invasive diagnosis, monitoring, and treatment susceptibility testing in human cancers. However, accurate detection of variant alleles, particularly during untargeted searches, remains a principal obstacle to widespread application of cell-f...

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Detalles Bibliográficos
Autores principales: Hellwig, Sabine, Nix, David A., Gligorich, Keith M., O’Shea, John M., Thomas, Alun, Fuertes, Carrie L., Bhetariya, Preetida J., Marth, Gabor T., Bronner, Mary P., Underhill, Hunter R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6059400/
https://www.ncbi.nlm.nih.gov/pubmed/30044795
http://dx.doi.org/10.1371/journal.pone.0197333

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6059400/
https://www.ncbi.nlm.nih.gov/pubmed/30044795
http://dx.doi.org/10.1371/journal.pone.0197333

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