Fast Temperature-Gradient COLD PCR for the enrichment of the paternally inherited SNPs in cell free fetal DNA; an application to non-invasive prenatal diagnosis of β-thalassaemia

OBJECTIVE: To develop a sensitive, specific, simple, cost-effective and reproducible platform for the non-invasive prenatal detection of paternally inherited alleles for β-thalassaemia. The development of such an assay is of major significance in order to replace currently-applied invasive methods c...

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Detalles Bibliográficos
Autores principales: Byrou, Stefania, Makrigiorgos, G. Mike, Christofides, Agathoklis, Kallikas, Ioannis, Papasavva, Thessalia, Kleanthous, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6059429/
https://www.ncbi.nlm.nih.gov/pubmed/30044883
http://dx.doi.org/10.1371/journal.pone.0200348

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