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Discovery of fragments that target key interactions in the signal recognition particle (SRP) as potential leads for a new class of antibiotics

Given the increasing incidence of antibiotic resistance, antibiotics that employ new strategies are urgently needed. Bacterial survival is dependent on proper function of the signal recognition particle (SRP) and its receptor (FtsY). A unique set of interactions in FtsY:SRP-RNA represents a promisin...

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Detalles Bibliográficos
Autores principales:	Faoro, Camilla, Wilkinson-White, Lorna, Kwan, Ann H., Ataide, Sandro F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6059433/ https://www.ncbi.nlm.nih.gov/pubmed/30044812 http://dx.doi.org/10.1371/journal.pone.0200387

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