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Biophysical clocks face a trade-off between internal and external noise resistance

Many organisms use free running circadian clocks to anticipate the day night cycle. However, others organisms use simple stimulus-response strategies (‘hourglass clocks’) and it is not clear when such strategies are sufficient or even preferable to free running clocks. Here, we find that free runnin...

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Autores principales: Pittayakanchit, Weerapat, Lu, Zhiyue, Chew, Justin, Rust, Michael J, Murugan, Arvind
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6059770/
https://www.ncbi.nlm.nih.gov/pubmed/29988019
http://dx.doi.org/10.7554/eLife.37624
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author Pittayakanchit, Weerapat
Lu, Zhiyue
Chew, Justin
Rust, Michael J
Murugan, Arvind
author_facet Pittayakanchit, Weerapat
Lu, Zhiyue
Chew, Justin
Rust, Michael J
Murugan, Arvind
author_sort Pittayakanchit, Weerapat
collection PubMed
description Many organisms use free running circadian clocks to anticipate the day night cycle. However, others organisms use simple stimulus-response strategies (‘hourglass clocks’) and it is not clear when such strategies are sufficient or even preferable to free running clocks. Here, we find that free running clocks, such as those found in the cyanobacterium Synechococcus elongatus and humans, can efficiently project out light intensity fluctuations due to weather patterns (‘external noise’) by exploiting their limit cycle attractor. However, such limit cycles are necessarily vulnerable to ‘internal noise’. Hence, at sufficiently high internal noise, point attractor-based ‘hourglass’ clocks, such as those found in a smaller cyanobacterium with low protein copy number, Prochlorococcus marinus, can outperform free running clocks. By interpolating between these two regimes in a diverse range of oscillators drawn from across biology, we demonstrate biochemical clock architectures that are best suited to different relative strengths of external and internal noise.
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spelling pubmed-60597702018-07-27 Biophysical clocks face a trade-off between internal and external noise resistance Pittayakanchit, Weerapat Lu, Zhiyue Chew, Justin Rust, Michael J Murugan, Arvind eLife Computational and Systems Biology Many organisms use free running circadian clocks to anticipate the day night cycle. However, others organisms use simple stimulus-response strategies (‘hourglass clocks’) and it is not clear when such strategies are sufficient or even preferable to free running clocks. Here, we find that free running clocks, such as those found in the cyanobacterium Synechococcus elongatus and humans, can efficiently project out light intensity fluctuations due to weather patterns (‘external noise’) by exploiting their limit cycle attractor. However, such limit cycles are necessarily vulnerable to ‘internal noise’. Hence, at sufficiently high internal noise, point attractor-based ‘hourglass’ clocks, such as those found in a smaller cyanobacterium with low protein copy number, Prochlorococcus marinus, can outperform free running clocks. By interpolating between these two regimes in a diverse range of oscillators drawn from across biology, we demonstrate biochemical clock architectures that are best suited to different relative strengths of external and internal noise. eLife Sciences Publications, Ltd 2018-07-10 /pmc/articles/PMC6059770/ /pubmed/29988019 http://dx.doi.org/10.7554/eLife.37624 Text en © 2018, Pittayakanchit et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Computational and Systems Biology
Pittayakanchit, Weerapat
Lu, Zhiyue
Chew, Justin
Rust, Michael J
Murugan, Arvind
Biophysical clocks face a trade-off between internal and external noise resistance
title Biophysical clocks face a trade-off between internal and external noise resistance
title_full Biophysical clocks face a trade-off between internal and external noise resistance
title_fullStr Biophysical clocks face a trade-off between internal and external noise resistance
title_full_unstemmed Biophysical clocks face a trade-off between internal and external noise resistance
title_short Biophysical clocks face a trade-off between internal and external noise resistance
title_sort biophysical clocks face a trade-off between internal and external noise resistance
topic Computational and Systems Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6059770/
https://www.ncbi.nlm.nih.gov/pubmed/29988019
http://dx.doi.org/10.7554/eLife.37624
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