Cargando…
Biophysical clocks face a trade-off between internal and external noise resistance
Many organisms use free running circadian clocks to anticipate the day night cycle. However, others organisms use simple stimulus-response strategies (‘hourglass clocks’) and it is not clear when such strategies are sufficient or even preferable to free running clocks. Here, we find that free runnin...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6059770/ https://www.ncbi.nlm.nih.gov/pubmed/29988019 http://dx.doi.org/10.7554/eLife.37624 |
_version_ | 1783341926283476992 |
---|---|
author | Pittayakanchit, Weerapat Lu, Zhiyue Chew, Justin Rust, Michael J Murugan, Arvind |
author_facet | Pittayakanchit, Weerapat Lu, Zhiyue Chew, Justin Rust, Michael J Murugan, Arvind |
author_sort | Pittayakanchit, Weerapat |
collection | PubMed |
description | Many organisms use free running circadian clocks to anticipate the day night cycle. However, others organisms use simple stimulus-response strategies (‘hourglass clocks’) and it is not clear when such strategies are sufficient or even preferable to free running clocks. Here, we find that free running clocks, such as those found in the cyanobacterium Synechococcus elongatus and humans, can efficiently project out light intensity fluctuations due to weather patterns (‘external noise’) by exploiting their limit cycle attractor. However, such limit cycles are necessarily vulnerable to ‘internal noise’. Hence, at sufficiently high internal noise, point attractor-based ‘hourglass’ clocks, such as those found in a smaller cyanobacterium with low protein copy number, Prochlorococcus marinus, can outperform free running clocks. By interpolating between these two regimes in a diverse range of oscillators drawn from across biology, we demonstrate biochemical clock architectures that are best suited to different relative strengths of external and internal noise. |
format | Online Article Text |
id | pubmed-6059770 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-60597702018-07-27 Biophysical clocks face a trade-off between internal and external noise resistance Pittayakanchit, Weerapat Lu, Zhiyue Chew, Justin Rust, Michael J Murugan, Arvind eLife Computational and Systems Biology Many organisms use free running circadian clocks to anticipate the day night cycle. However, others organisms use simple stimulus-response strategies (‘hourglass clocks’) and it is not clear when such strategies are sufficient or even preferable to free running clocks. Here, we find that free running clocks, such as those found in the cyanobacterium Synechococcus elongatus and humans, can efficiently project out light intensity fluctuations due to weather patterns (‘external noise’) by exploiting their limit cycle attractor. However, such limit cycles are necessarily vulnerable to ‘internal noise’. Hence, at sufficiently high internal noise, point attractor-based ‘hourglass’ clocks, such as those found in a smaller cyanobacterium with low protein copy number, Prochlorococcus marinus, can outperform free running clocks. By interpolating between these two regimes in a diverse range of oscillators drawn from across biology, we demonstrate biochemical clock architectures that are best suited to different relative strengths of external and internal noise. eLife Sciences Publications, Ltd 2018-07-10 /pmc/articles/PMC6059770/ /pubmed/29988019 http://dx.doi.org/10.7554/eLife.37624 Text en © 2018, Pittayakanchit et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Computational and Systems Biology Pittayakanchit, Weerapat Lu, Zhiyue Chew, Justin Rust, Michael J Murugan, Arvind Biophysical clocks face a trade-off between internal and external noise resistance |
title | Biophysical clocks face a trade-off between internal and external noise resistance |
title_full | Biophysical clocks face a trade-off between internal and external noise resistance |
title_fullStr | Biophysical clocks face a trade-off between internal and external noise resistance |
title_full_unstemmed | Biophysical clocks face a trade-off between internal and external noise resistance |
title_short | Biophysical clocks face a trade-off between internal and external noise resistance |
title_sort | biophysical clocks face a trade-off between internal and external noise resistance |
topic | Computational and Systems Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6059770/ https://www.ncbi.nlm.nih.gov/pubmed/29988019 http://dx.doi.org/10.7554/eLife.37624 |
work_keys_str_mv | AT pittayakanchitweerapat biophysicalclocksfaceatradeoffbetweeninternalandexternalnoiseresistance AT luzhiyue biophysicalclocksfaceatradeoffbetweeninternalandexternalnoiseresistance AT chewjustin biophysicalclocksfaceatradeoffbetweeninternalandexternalnoiseresistance AT rustmichaelj biophysicalclocksfaceatradeoffbetweeninternalandexternalnoiseresistance AT muruganarvind biophysicalclocksfaceatradeoffbetweeninternalandexternalnoiseresistance |