Apolipoprotein A-I Reduces In-Stent Restenosis and Platelet Activation and Alters Neointimal Cellular Phenotype

Even the most advanced drug-eluting stents evoke unresolved issues, including chronic inflammation, late thrombosis, and neoatherosclerosis. This highlights the need for novel strategies that improve stent biocompatibility. Our studies show that apolipoprotein A-I (apoA-I) reduces in-stent restenosi...

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Autores principales: Vanags, Laura Z., Tan, Joanne T.M., Galougahi, Keyvan K., Schaefer, Andreas, Wise, Steven G., Murphy, Andrew, Ali, Ziad A., Bursill, Christina A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
PRECLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060078/
https://www.ncbi.nlm.nih.gov/pubmed/30062205
http://dx.doi.org/10.1016/j.jacbts.2017.11.006
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author Vanags, Laura Z.
Tan, Joanne T.M.
Galougahi, Keyvan K.
Schaefer, Andreas
Wise, Steven G.
Murphy, Andrew
Ali, Ziad A.
Bursill, Christina A.
author_facet Vanags, Laura Z.
Tan, Joanne T.M.
Galougahi, Keyvan K.
Schaefer, Andreas
Wise, Steven G.
Murphy, Andrew
Ali, Ziad A.
Bursill, Christina A.
author_sort Vanags, Laura Z.
collection PubMed
description Even the most advanced drug-eluting stents evoke unresolved issues, including chronic inflammation, late thrombosis, and neoatherosclerosis. This highlights the need for novel strategies that improve stent biocompatibility. Our studies show that apolipoprotein A-I (apoA-I) reduces in-stent restenosis and platelet activation, and enhances endothelialization. These findings have therapeutic implications for improving stent biocompatibility.
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spelling pubmed-60600782018-07-30 Apolipoprotein A-I Reduces In-Stent Restenosis and Platelet Activation and Alters Neointimal Cellular Phenotype Vanags, Laura Z. Tan, Joanne T.M. Galougahi, Keyvan K. Schaefer, Andreas Wise, Steven G. Murphy, Andrew Ali, Ziad A. Bursill, Christina A. JACC Basic Transl Sci PRECLINICAL RESEARCH Even the most advanced drug-eluting stents evoke unresolved issues, including chronic inflammation, late thrombosis, and neoatherosclerosis. This highlights the need for novel strategies that improve stent biocompatibility. Our studies show that apolipoprotein A-I (apoA-I) reduces in-stent restenosis and platelet activation, and enhances endothelialization. These findings have therapeutic implications for improving stent biocompatibility. Elsevier 2018-05-30 /pmc/articles/PMC6060078/ /pubmed/30062205 http://dx.doi.org/10.1016/j.jacbts.2017.11.006 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle PRECLINICAL RESEARCH
Vanags, Laura Z.
Tan, Joanne T.M.
Galougahi, Keyvan K.
Schaefer, Andreas
Wise, Steven G.
Murphy, Andrew
Ali, Ziad A.
Bursill, Christina A.
Apolipoprotein A-I Reduces In-Stent Restenosis and Platelet Activation and Alters Neointimal Cellular Phenotype
title Apolipoprotein A-I Reduces In-Stent Restenosis and Platelet Activation and Alters Neointimal Cellular Phenotype
title_full Apolipoprotein A-I Reduces In-Stent Restenosis and Platelet Activation and Alters Neointimal Cellular Phenotype
title_fullStr Apolipoprotein A-I Reduces In-Stent Restenosis and Platelet Activation and Alters Neointimal Cellular Phenotype
title_full_unstemmed Apolipoprotein A-I Reduces In-Stent Restenosis and Platelet Activation and Alters Neointimal Cellular Phenotype
title_short Apolipoprotein A-I Reduces In-Stent Restenosis and Platelet Activation and Alters Neointimal Cellular Phenotype
title_sort apolipoprotein a-i reduces in-stent restenosis and platelet activation and alters neointimal cellular phenotype
topic PRECLINICAL RESEARCH
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060078/
https://www.ncbi.nlm.nih.gov/pubmed/30062205
http://dx.doi.org/10.1016/j.jacbts.2017.11.006
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