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Facile, environmentally benign and scalable approach to produce pristine few layers graphene suitable for preparing biocompatible polymer nanocomposites

The success of developing graphene based biomaterials depends on its ease of synthesis, use of environmentally benign methods and low toxicity of the chemicals involved as well as biocompatibility of the final products/devices. We report, herein, a simple, scalable and safe method to produce defect...

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Autores principales: George, Gejo, Sisupal, Suja Bhargavan, Tomy, Teenu, Kumaran, Alaganandam, Vadivelu, Prabha, Suvekbala, Vemparthan, Sivaram, Swaminathan, Ragupathy, Lakshminarayanan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060110/
https://www.ncbi.nlm.nih.gov/pubmed/30046158
http://dx.doi.org/10.1038/s41598-018-28560-1
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author George, Gejo
Sisupal, Suja Bhargavan
Tomy, Teenu
Kumaran, Alaganandam
Vadivelu, Prabha
Suvekbala, Vemparthan
Sivaram, Swaminathan
Ragupathy, Lakshminarayanan
author_facet George, Gejo
Sisupal, Suja Bhargavan
Tomy, Teenu
Kumaran, Alaganandam
Vadivelu, Prabha
Suvekbala, Vemparthan
Sivaram, Swaminathan
Ragupathy, Lakshminarayanan
author_sort George, Gejo
collection PubMed
description The success of developing graphene based biomaterials depends on its ease of synthesis, use of environmentally benign methods and low toxicity of the chemicals involved as well as biocompatibility of the final products/devices. We report, herein, a simple, scalable and safe method to produce defect free few layers graphene using naturally available phenolics i.e. curcumin/tetrahydrocurcumin/quercetin, as solid-phase exfoliating agents with a productivity of ∼45 g/batch (D/G ≤ 0.54 and D/D′ ≤ 1.23). The production method can also be employed in liquid-phase using a ball mill (20 g/batch, D/G ≤ 0.23 and D/D′ ≤ 1.12) and a sand grinder (10 g/batch, D/G ≤ 0.11 and D/D∼ ≤ 0.78). The combined effect of π-π interaction and charge transfer (from curcumin to graphene) is postulated to be the driving force for efficient exfoliation of graphite. The yielded graphene was mixed with the natural rubber (NR) latex to produce thin film nanocomposites, which show superior tensile strength with low modulus and no loss of % elongation at break. In-vitro and in-vivo investigations demonstrate that the prepared nanocomposite is biocompatible. This approach could be useful for the production of materials suitable in products (gloves/condoms/catheters), which come in contact with body parts/body fluids.
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spelling pubmed-60601102018-07-31 Facile, environmentally benign and scalable approach to produce pristine few layers graphene suitable for preparing biocompatible polymer nanocomposites George, Gejo Sisupal, Suja Bhargavan Tomy, Teenu Kumaran, Alaganandam Vadivelu, Prabha Suvekbala, Vemparthan Sivaram, Swaminathan Ragupathy, Lakshminarayanan Sci Rep Article The success of developing graphene based biomaterials depends on its ease of synthesis, use of environmentally benign methods and low toxicity of the chemicals involved as well as biocompatibility of the final products/devices. We report, herein, a simple, scalable and safe method to produce defect free few layers graphene using naturally available phenolics i.e. curcumin/tetrahydrocurcumin/quercetin, as solid-phase exfoliating agents with a productivity of ∼45 g/batch (D/G ≤ 0.54 and D/D′ ≤ 1.23). The production method can also be employed in liquid-phase using a ball mill (20 g/batch, D/G ≤ 0.23 and D/D′ ≤ 1.12) and a sand grinder (10 g/batch, D/G ≤ 0.11 and D/D∼ ≤ 0.78). The combined effect of π-π interaction and charge transfer (from curcumin to graphene) is postulated to be the driving force for efficient exfoliation of graphite. The yielded graphene was mixed with the natural rubber (NR) latex to produce thin film nanocomposites, which show superior tensile strength with low modulus and no loss of % elongation at break. In-vitro and in-vivo investigations demonstrate that the prepared nanocomposite is biocompatible. This approach could be useful for the production of materials suitable in products (gloves/condoms/catheters), which come in contact with body parts/body fluids. Nature Publishing Group UK 2018-07-25 /pmc/articles/PMC6060110/ /pubmed/30046158 http://dx.doi.org/10.1038/s41598-018-28560-1 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
George, Gejo
Sisupal, Suja Bhargavan
Tomy, Teenu
Kumaran, Alaganandam
Vadivelu, Prabha
Suvekbala, Vemparthan
Sivaram, Swaminathan
Ragupathy, Lakshminarayanan
Facile, environmentally benign and scalable approach to produce pristine few layers graphene suitable for preparing biocompatible polymer nanocomposites
title Facile, environmentally benign and scalable approach to produce pristine few layers graphene suitable for preparing biocompatible polymer nanocomposites
title_full Facile, environmentally benign and scalable approach to produce pristine few layers graphene suitable for preparing biocompatible polymer nanocomposites
title_fullStr Facile, environmentally benign and scalable approach to produce pristine few layers graphene suitable for preparing biocompatible polymer nanocomposites
title_full_unstemmed Facile, environmentally benign and scalable approach to produce pristine few layers graphene suitable for preparing biocompatible polymer nanocomposites
title_short Facile, environmentally benign and scalable approach to produce pristine few layers graphene suitable for preparing biocompatible polymer nanocomposites
title_sort facile, environmentally benign and scalable approach to produce pristine few layers graphene suitable for preparing biocompatible polymer nanocomposites
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060110/
https://www.ncbi.nlm.nih.gov/pubmed/30046158
http://dx.doi.org/10.1038/s41598-018-28560-1
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