Intradermal immunization by Ebola virus GP subunit vaccines using microneedle patches protects mice against lethal EBOV challenge

Development of a safe and efficacious filovirus vaccine is of high importance to public health. In this study, we compared immune responses induced by Ebola virus (EBOV) glycoprotein (GP) subunit vaccines via intradermal immunization with microneedle (MN) patches and the conventional intramuscular (...

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Detalles Bibliográficos
Autores principales: Liu, Ying, Ye, Ling, Lin, Fang, Gomaa, Yasmine, Flyer, David, Carrion, Ricardo, Patterson, Jean L., Prausnitz, Mark R., Smith, Gale, Glenn, Gregory, Wu, Hua, Compans, Richard W., Yang, Chinglai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060117/
https://www.ncbi.nlm.nih.gov/pubmed/30046140
http://dx.doi.org/10.1038/s41598-018-29135-w

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