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PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity

Electrocardiographic PR interval measures atrio-ventricular depolarization and conduction, and abnormal PR interval is a risk factor for atrial fibrillation and heart block. Our genome-wide association study of over 92,000 European-descent individuals identifies 44 PR interval loci (34 novel). Exami...

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Autores principales: van Setten, Jessica, Brody, Jennifer A., Jamshidi, Yalda, Swenson, Brenton R., Butler, Anne M., Campbell, Harry, Del Greco, Fabiola M., Evans, Daniel S., Gibson, Quince, Gudbjartsson, Daniel F., Kerr, Kathleen F., Krijthe, Bouwe P., Lyytikäinen, Leo-Pekka, Müller, Christian, Müller-Nurasyid, Martina, Nolte, Ilja M., Padmanabhan, Sandosh, Ritchie, Marylyn D., Robino, Antonietta, Smith, Albert V., Steri, Maristella, Tanaka, Toshiko, Teumer, Alexander, Trompet, Stella, Ulivi, Sheila, Verweij, Niek, Yin, Xiaoyan, Arnar, David O., Asselbergs, Folkert W., Bader, Joel S., Barnard, John, Bis, Josh, Blankenberg, Stefan, Boerwinkle, Eric, Bradford, Yuki, Buckley, Brendan M., Chung, Mina K., Crawford, Dana, den Hoed, Marcel, Denny, Josh C., Dominiczak, Anna F., Ehret, Georg B., Eijgelsheim, Mark, Ellinor, Patrick T., Felix, Stephan B., Franco, Oscar H., Franke, Lude, Harris, Tamara B., Holm, Hilma, Ilaria, Gandin, Iorio, Annamaria, Kähönen, Mika, Kolcic, Ivana, Kors, Jan A., Lakatta, Edward G., Launer, Lenore J., Lin, Honghuang, Lin, Henry J., Loos, Ruth J. F., Lubitz, Steven A., Macfarlane, Peter W., Magnani, Jared W., Leach, Irene Mateo, Meitinger, Thomas, Mitchell, Braxton D., Munzel, Thomas, Papanicolaou, George J., Peters, Annette, Pfeufer, Arne, Pramstaller, Peter P., Raitakari, Olli T., Rotter, Jerome I., Rudan, Igor, Samani, Nilesh J., Schlessinger, David, Silva Aldana, Claudia T., Sinner, Moritz F., Smith, Jonathan D., Snieder, Harold, Soliman, Elsayed Z., Spector, Timothy D., Stott, David J., Strauch, Konstantin, Tarasov, Kirill V., Thorsteinsdottir, Unnur, Uitterlinden, Andre G., Van Wagoner, David R., Völker, Uwe, Völzke, Henry, Waldenberger, Melanie, Jan Westra, Harm, Wild, Philipp S., Zeller, Tanja, Alonso, Alvaro, Avery, Christy L., Bandinelli, Stefania, Benjamin, Emelia J., Cucca, Francesco, Dörr, Marcus, Ferrucci, Luigi, Gasparini, Paolo, Gudnason, Vilmundur, Hayward, Caroline, Heckbert, Susan R., Hicks, Andrew A., Jukema, J. Wouter, Kääb, Stefan, Lehtimäki, Terho, Liu, Yongmei, Munroe, Patricia B., Parsa, Afshin, Polasek, Ozren, Psaty, Bruce M., Roden, Dan M., Schnabel, Renate B., Sinagra, Gianfranco, Stefansson, Kari, Stricker, Bruno H., van der Harst, Pim, van Duijn, Cornelia M., Wilson, James F., Gharib, Sina A., de Bakker, Paul I. W., Isaacs, Aaron, Arking, Dan E., Sotoodehnia, Nona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060178/
https://www.ncbi.nlm.nih.gov/pubmed/30046033
http://dx.doi.org/10.1038/s41467-018-04766-9