Plasma Ceramides as Prognostic Biomarkers and Their Arterial and Myocardial Tissue Correlates in Acute Myocardial Infarction

We identified a plasma signature of 11 C14 to C26 ceramides and 1 C16 dihydroceramide predictive of major adverse cardiovascular events in patients with acute myocardial infarction (AMI). Among patients undergoing coronary artery bypass surgery, those with recent AMI, compared with those without rec...

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Detalles Bibliográficos
Autores principales: de Carvalho, Leonardo P., Tan, Sock Hwee, Ow, Ghim-Siong, Tang, Zhiqun, Ching, Jianhong, Kovalik, Jean-Paul, Poh, Sock Cheng, Chin, Chee-Tang, Richards, A. Mark, Martinez, Eliana C., Troughton, Richard W., Fong, Alan Yean-Yip, Yan, Bryan P., Seneviratna, Aruni, Sorokin, Vitaly, Summers, Scott A., Kuznetsov, Vladimir A., Chan, Mark Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
CLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060200/
https://www.ncbi.nlm.nih.gov/pubmed/30062203
http://dx.doi.org/10.1016/j.jacbts.2017.12.005
Descripción
Sumario:We identified a plasma signature of 11 C14 to C26 ceramides and 1 C16 dihydroceramide predictive of major adverse cardiovascular events in patients with acute myocardial infarction (AMI). Among patients undergoing coronary artery bypass surgery, those with recent AMI, compared with those without recent AMI, showed a significant increase in 5 of the signature’s 12 ceramides in plasma but not simultaneously-biopsied aortic tissue. In contrast, a rat AMI model, compared with sham control, showed a significant increase in myocardial concentrations of all 12 ceramides and up-regulation of 3 ceramide-producing enzymes, suggesting ischemic myocardium as a possible source of this ceramide signature.

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