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Plasma Ceramides as Prognostic Biomarkers and Their Arterial and Myocardial Tissue Correlates in Acute Myocardial Infarction
We identified a plasma signature of 11 C14 to C26 ceramides and 1 C16 dihydroceramide predictive of major adverse cardiovascular events in patients with acute myocardial infarction (AMI). Among patients undergoing coronary artery bypass surgery, those with recent AMI, compared with those without rec...
| Autores principales: | , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060200/ https://www.ncbi.nlm.nih.gov/pubmed/30062203 http://dx.doi.org/10.1016/j.jacbts.2017.12.005 |
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| author | de Carvalho, Leonardo P. Tan, Sock Hwee Ow, Ghim-Siong Tang, Zhiqun Ching, Jianhong Kovalik, Jean-Paul Poh, Sock Cheng Chin, Chee-Tang Richards, A. Mark Martinez, Eliana C. Troughton, Richard W. Fong, Alan Yean-Yip Yan, Bryan P. Seneviratna, Aruni Sorokin, Vitaly Summers, Scott A. Kuznetsov, Vladimir A. Chan, Mark Y. |
| author_facet | de Carvalho, Leonardo P. Tan, Sock Hwee Ow, Ghim-Siong Tang, Zhiqun Ching, Jianhong Kovalik, Jean-Paul Poh, Sock Cheng Chin, Chee-Tang Richards, A. Mark Martinez, Eliana C. Troughton, Richard W. Fong, Alan Yean-Yip Yan, Bryan P. Seneviratna, Aruni Sorokin, Vitaly Summers, Scott A. Kuznetsov, Vladimir A. Chan, Mark Y. |
| author_sort | de Carvalho, Leonardo P. |
| collection | PubMed |
| description | We identified a plasma signature of 11 C14 to C26 ceramides and 1 C16 dihydroceramide predictive of major adverse cardiovascular events in patients with acute myocardial infarction (AMI). Among patients undergoing coronary artery bypass surgery, those with recent AMI, compared with those without recent AMI, showed a significant increase in 5 of the signature’s 12 ceramides in plasma but not simultaneously-biopsied aortic tissue. In contrast, a rat AMI model, compared with sham control, showed a significant increase in myocardial concentrations of all 12 ceramides and up-regulation of 3 ceramide-producing enzymes, suggesting ischemic myocardium as a possible source of this ceramide signature. |
| format | Online Article Text |
| id | pubmed-6060200 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| publisher | Elsevier |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-60602002018-07-30 Plasma Ceramides as Prognostic Biomarkers and Their Arterial and Myocardial Tissue Correlates in Acute Myocardial Infarction de Carvalho, Leonardo P. Tan, Sock Hwee Ow, Ghim-Siong Tang, Zhiqun Ching, Jianhong Kovalik, Jean-Paul Poh, Sock Cheng Chin, Chee-Tang Richards, A. Mark Martinez, Eliana C. Troughton, Richard W. Fong, Alan Yean-Yip Yan, Bryan P. Seneviratna, Aruni Sorokin, Vitaly Summers, Scott A. Kuznetsov, Vladimir A. Chan, Mark Y. JACC Basic Transl Sci CLINICAL RESEARCH We identified a plasma signature of 11 C14 to C26 ceramides and 1 C16 dihydroceramide predictive of major adverse cardiovascular events in patients with acute myocardial infarction (AMI). Among patients undergoing coronary artery bypass surgery, those with recent AMI, compared with those without recent AMI, showed a significant increase in 5 of the signature’s 12 ceramides in plasma but not simultaneously-biopsied aortic tissue. In contrast, a rat AMI model, compared with sham control, showed a significant increase in myocardial concentrations of all 12 ceramides and up-regulation of 3 ceramide-producing enzymes, suggesting ischemic myocardium as a possible source of this ceramide signature. Elsevier 2018-05-30 /pmc/articles/PMC6060200/ /pubmed/30062203 http://dx.doi.org/10.1016/j.jacbts.2017.12.005 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | CLINICAL RESEARCH de Carvalho, Leonardo P. Tan, Sock Hwee Ow, Ghim-Siong Tang, Zhiqun Ching, Jianhong Kovalik, Jean-Paul Poh, Sock Cheng Chin, Chee-Tang Richards, A. Mark Martinez, Eliana C. Troughton, Richard W. Fong, Alan Yean-Yip Yan, Bryan P. Seneviratna, Aruni Sorokin, Vitaly Summers, Scott A. Kuznetsov, Vladimir A. Chan, Mark Y. Plasma Ceramides as Prognostic Biomarkers and Their Arterial and Myocardial Tissue Correlates in Acute Myocardial Infarction |
| title | Plasma Ceramides as Prognostic Biomarkers and Their Arterial and Myocardial Tissue Correlates in Acute Myocardial Infarction |
| title_full | Plasma Ceramides as Prognostic Biomarkers and Their Arterial and Myocardial Tissue Correlates in Acute Myocardial Infarction |
| title_fullStr | Plasma Ceramides as Prognostic Biomarkers and Their Arterial and Myocardial Tissue Correlates in Acute Myocardial Infarction |
| title_full_unstemmed | Plasma Ceramides as Prognostic Biomarkers and Their Arterial and Myocardial Tissue Correlates in Acute Myocardial Infarction |
| title_short | Plasma Ceramides as Prognostic Biomarkers and Their Arterial and Myocardial Tissue Correlates in Acute Myocardial Infarction |
| title_sort | plasma ceramides as prognostic biomarkers and their arterial and myocardial tissue correlates in acute myocardial infarction |
| topic | CLINICAL RESEARCH |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060200/ https://www.ncbi.nlm.nih.gov/pubmed/30062203 http://dx.doi.org/10.1016/j.jacbts.2017.12.005 |
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