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Spatial Properties of Mismatch Negativity in Patients with Disorders of Consciousness

In recent decades, event-related potentials have been used for the clinical electrophysiological assessment of patients with disorders of consciousness (DOCs). In this paper, an oddball paradigm with two types of frequency-deviant stimulus (standard stimuli were pure tones of 1000 Hz; small deviant...

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Autores principales: Wang, Xiaoyu, Fu, Rao, Xia, Xiaoyu, Chen, Xueling, Wu, Han, Landi, Nicole, Pugh, Ken, He, Jianghong, Cong, Fengyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060209/
https://www.ncbi.nlm.nih.gov/pubmed/30030749
http://dx.doi.org/10.1007/s12264-018-0260-4
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author Wang, Xiaoyu
Fu, Rao
Xia, Xiaoyu
Chen, Xueling
Wu, Han
Landi, Nicole
Pugh, Ken
He, Jianghong
Cong, Fengyu
author_facet Wang, Xiaoyu
Fu, Rao
Xia, Xiaoyu
Chen, Xueling
Wu, Han
Landi, Nicole
Pugh, Ken
He, Jianghong
Cong, Fengyu
author_sort Wang, Xiaoyu
collection PubMed
description In recent decades, event-related potentials have been used for the clinical electrophysiological assessment of patients with disorders of consciousness (DOCs). In this paper, an oddball paradigm with two types of frequency-deviant stimulus (standard stimuli were pure tones of 1000 Hz; small deviant stimuli were pure tones of 1050 Hz; large deviant stimuli were pure tones of 1200 Hz) was applied to elicit mismatch negativity (MMN) in 30 patients with DOCs diagnosed using the JFK Coma Recovery Scale-Revised (CRS-R). The results showed that the peak amplitudes of MMN elicited by both large and small deviant stimuli were significantly different from baseline. In terms of the spatial properties of MMN, a significant interaction effect between conditions (small and large deviant stimuli) and electrode nodes was centered at the frontocentral area. Furthermore, correlation coefficients were calculated between MMN amplitudes and CRS-R scores for each electrode among all participants to generate topographic maps. Meanwhile, a significant negative correlation between the MMN amplitudes elicited by large deviant stimuli and the CRS-R scores was also found at the frontocentral area. In consequence, our results combine the above spatial properties of MMN in patients with DOCs, and provide a more precise location (frontocentral area) at which to evaluate the correlation between clinical electrophysiological assessment and the level of consciousness.
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spelling pubmed-60602092018-08-07 Spatial Properties of Mismatch Negativity in Patients with Disorders of Consciousness Wang, Xiaoyu Fu, Rao Xia, Xiaoyu Chen, Xueling Wu, Han Landi, Nicole Pugh, Ken He, Jianghong Cong, Fengyu Neurosci Bull Original Article In recent decades, event-related potentials have been used for the clinical electrophysiological assessment of patients with disorders of consciousness (DOCs). In this paper, an oddball paradigm with two types of frequency-deviant stimulus (standard stimuli were pure tones of 1000 Hz; small deviant stimuli were pure tones of 1050 Hz; large deviant stimuli were pure tones of 1200 Hz) was applied to elicit mismatch negativity (MMN) in 30 patients with DOCs diagnosed using the JFK Coma Recovery Scale-Revised (CRS-R). The results showed that the peak amplitudes of MMN elicited by both large and small deviant stimuli were significantly different from baseline. In terms of the spatial properties of MMN, a significant interaction effect between conditions (small and large deviant stimuli) and electrode nodes was centered at the frontocentral area. Furthermore, correlation coefficients were calculated between MMN amplitudes and CRS-R scores for each electrode among all participants to generate topographic maps. Meanwhile, a significant negative correlation between the MMN amplitudes elicited by large deviant stimuli and the CRS-R scores was also found at the frontocentral area. In consequence, our results combine the above spatial properties of MMN in patients with DOCs, and provide a more precise location (frontocentral area) at which to evaluate the correlation between clinical electrophysiological assessment and the level of consciousness. Springer Singapore 2018-07-20 /pmc/articles/PMC6060209/ /pubmed/30030749 http://dx.doi.org/10.1007/s12264-018-0260-4 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Wang, Xiaoyu
Fu, Rao
Xia, Xiaoyu
Chen, Xueling
Wu, Han
Landi, Nicole
Pugh, Ken
He, Jianghong
Cong, Fengyu
Spatial Properties of Mismatch Negativity in Patients with Disorders of Consciousness
title Spatial Properties of Mismatch Negativity in Patients with Disorders of Consciousness
title_full Spatial Properties of Mismatch Negativity in Patients with Disorders of Consciousness
title_fullStr Spatial Properties of Mismatch Negativity in Patients with Disorders of Consciousness
title_full_unstemmed Spatial Properties of Mismatch Negativity in Patients with Disorders of Consciousness
title_short Spatial Properties of Mismatch Negativity in Patients with Disorders of Consciousness
title_sort spatial properties of mismatch negativity in patients with disorders of consciousness
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060209/
https://www.ncbi.nlm.nih.gov/pubmed/30030749
http://dx.doi.org/10.1007/s12264-018-0260-4
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