Synthesis, Antiviral, and Antimicrobial Evaluation of Benzyl Protected Diversified C-nucleosides

Formyl glycals are the versatile synthetic intermediates and can serves as precursor for the synthesis of various C and N-nucleosides. Due to the presence of electron donating and electron withdrawing character on formyl sugars which makes the molecule more susceptible to nucleophilic attack. Utiliz...

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Detalles Bibliográficos
Autores principales: Bari, Ahmed, Ali, Syed S., Alanazi, Amer M., Mashwani, Muhammad A., Al-Obaid, Abdulrahman M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060234/
https://www.ncbi.nlm.nih.gov/pubmed/30073161
http://dx.doi.org/10.3389/fchem.2018.00294
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author Bari, Ahmed
Ali, Syed S.
Alanazi, Amer M.
Mashwani, Muhammad A.
Al-Obaid, Abdulrahman M.
author_facet Bari, Ahmed
Ali, Syed S.
Alanazi, Amer M.
Mashwani, Muhammad A.
Al-Obaid, Abdulrahman M.
author_sort Bari, Ahmed
collection PubMed
description Formyl glycals are the versatile synthetic intermediates and can serves as precursor for the synthesis of various C and N-nucleosides. Due to the presence of electron donating and electron withdrawing character on formyl sugars which makes the molecule more susceptible to nucleophilic attack. Utilizing same strategy, we propose the synthesis of diversified C-nucleosides (3-14) by reaction with N,N dinucleophiles. These nucleoside analogs were than tested against viral, bacterial and fungal strains.
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spelling pubmed-60602342018-08-02 Synthesis, Antiviral, and Antimicrobial Evaluation of Benzyl Protected Diversified C-nucleosides Bari, Ahmed Ali, Syed S. Alanazi, Amer M. Mashwani, Muhammad A. Al-Obaid, Abdulrahman M. Front Chem Chemistry Formyl glycals are the versatile synthetic intermediates and can serves as precursor for the synthesis of various C and N-nucleosides. Due to the presence of electron donating and electron withdrawing character on formyl sugars which makes the molecule more susceptible to nucleophilic attack. Utilizing same strategy, we propose the synthesis of diversified C-nucleosides (3-14) by reaction with N,N dinucleophiles. These nucleoside analogs were than tested against viral, bacterial and fungal strains. Frontiers Media S.A. 2018-07-19 /pmc/articles/PMC6060234/ /pubmed/30073161 http://dx.doi.org/10.3389/fchem.2018.00294 Text en Copyright © 2018 Bari, Ali, Alanazi, Mashwani and Al-Obaid. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Bari, Ahmed
Ali, Syed S.
Alanazi, Amer M.
Mashwani, Muhammad A.
Al-Obaid, Abdulrahman M.
Synthesis, Antiviral, and Antimicrobial Evaluation of Benzyl Protected Diversified C-nucleosides
title Synthesis, Antiviral, and Antimicrobial Evaluation of Benzyl Protected Diversified C-nucleosides
title_full Synthesis, Antiviral, and Antimicrobial Evaluation of Benzyl Protected Diversified C-nucleosides
title_fullStr Synthesis, Antiviral, and Antimicrobial Evaluation of Benzyl Protected Diversified C-nucleosides
title_full_unstemmed Synthesis, Antiviral, and Antimicrobial Evaluation of Benzyl Protected Diversified C-nucleosides
title_short Synthesis, Antiviral, and Antimicrobial Evaluation of Benzyl Protected Diversified C-nucleosides
title_sort synthesis, antiviral, and antimicrobial evaluation of benzyl protected diversified c-nucleosides
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060234/
https://www.ncbi.nlm.nih.gov/pubmed/30073161
http://dx.doi.org/10.3389/fchem.2018.00294
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