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Disruption of Amino Acid Homeostasis by Novel ASCT2 Inhibitors Involves Multiple Targets

The glutamine transporter ASCT2 (SLC1A5) is actively investigated as an oncological target, but the field lacks efficient ASCT2 inhibitors. A new group of ASCT2 inhibitors, 2-amino-4-bis(aryloxybenzyl)aminobutanoic acids (AABA), were developed recently and shown to suppress tumor growth in preclinic...

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Detalles Bibliográficos
Autores principales:	Bröer, Angelika, Fairweather, Stephen, Bröer, Stefan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060247/ https://www.ncbi.nlm.nih.gov/pubmed/30072900 http://dx.doi.org/10.3389/fphar.2018.00785

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