Cargando…

Pathological Proteins Are Transported by Extracellular Vesicles of Sporadic Amyotrophic Lateral Sclerosis Patients

Amyotrophic lateral sclerosis (ALS) is a progressive adult-onset neurodegenerative disease, that affects cortical, bulbar and spinal motor neurons, and it is considered a proteinopathy, in which pathological proteins (SOD1, TDP-43, and FUS) may accumulate and interfere with neuronal functions eventu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sproviero, Daisy, La Salvia, Sabrina, Giannini, Marta, Crippa, Valeria, Gagliardi, Stella, Bernuzzi, Stefano, Diamanti, Luca, Ceroni, Mauro, Pansarasa, Orietta, Poletti, Angelo, Cereda, Cristina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060258/ https://www.ncbi.nlm.nih.gov/pubmed/30072868 http://dx.doi.org/10.3389/fnins.2018.00487

Ejemplares similares

Nuclear Phospho-SOD1 Protects DNA from Oxidative Stress Damage in Amyotrophic Lateral Sclerosis
por: Bordoni, Matteo, et al.
Publicado: (2019)

Lymphoblastoid cell lines as a model to understand amyotrophic lateral sclerosis disease mechanisms
por: Pansarasa, Orietta, et al.
Publicado: (2018)

SOD1 in Amyotrophic Lateral Sclerosis: “Ambivalent” Behavior Connected to the Disease
por: Pansarasa, Orietta, et al.
Publicado: (2018)

Leukocyte Derived Microvesicles as Disease Progression Biomarkers in Slow Progressing Amyotrophic Lateral Sclerosis Patients
por: Sproviero, Daisy, et al.
Publicado: (2019)

RNA-Seq profiling in peripheral blood mononuclear cells of amyotrophic lateral sclerosis patients and controls
por: Zucca, Susanna, et al.
Publicado: (2019)

Altered Intracellular Localization of SOD1 in Leukocytes from Patients with Sporadic Amyotrophic Lateral Sclerosis
por: Cereda, Cristina, et al.
Publicado: (2013)

Long non-coding and coding RNAs characterization in Peripheral Blood Mononuclear Cells and Spinal Cord from Amyotrophic Lateral Sclerosis patients
por: Gagliardi, Stella, et al.
Publicado: (2018)

RNA Molecular Signature Profiling in PBMCs of Sporadic ALS Patients: HSP70 Overexpression Is Associated with Nuclear SOD1
por: Garofalo, Maria, et al.
Publicado: (2022)

Lysosomes Dysfunction Causes Mitophagy Impairment in PBMCs of Sporadic ALS Patients
por: Bordoni, Matteo, et al.
Publicado: (2022)

Different miRNA Profiles in Plasma Derived Small and Large Extracellular Vesicles from Patients with Neurodegenerative Diseases
por: Sproviero, Daisy, et al.
Publicado: (2021)

Extracellular Vesicles Derived From Plasma of Patients With Neurodegenerative Disease Have Common Transcriptomic Profiling
por: Sproviero, Daisy, et al.
Publicado: (2022)

Advances with Long Non-Coding RNAs in Alzheimer’s Disease as Peripheral Biomarker
por: Garofalo, Maria, et al.
Publicado: (2021)

The Role of VCP Mutations in the Spectrum of Amyotrophic Lateral Sclerosis—Frontotemporal Dementia
por: Scarian, Eveljn, et al.
Publicado: (2022)

Alzheimer’s, Parkinson’s Disease and Amyotrophic Lateral Sclerosis Gene Expression Patterns Divergence Reveals Different Grade of RNA Metabolism Involvement
por: Garofalo, Maria, et al.
Publicado: (2020)

Biomarkers in Human Peripheral Blood Mononuclear Cells: The State of the Art in Amyotrophic Lateral Sclerosis
por: Pansarasa, Orietta, et al.
Publicado: (2022)

Characterization of Mitochondrial Alterations in Aicardi–Goutières Patients Mutated in RNASEH2A and RNASEH2B Genes
por: Dragoni, Francesca, et al.
Publicado: (2022)

Detection of SARS-CoV-2 genome and whole transcriptome sequencing in frontal cortex of COVID-19 patients
por: Gagliardi, Stella, et al.
Publicado: (2021)

Patients’ Stem Cells Differentiation in a 3D Environment as a Promising Experimental Tool for the Study of Amyotrophic Lateral Sclerosis
por: Scarian, Eveljn, et al.
Publicado: (2022)

COVID-19 patients and Dementia: Frontal cortex transcriptomic data
por: Garofalo, Maria, et al.
Publicado: (2021)

TDP-43 mutations link Amyotrophic Lateral Sclerosis with R-loop homeostasis and R loop-mediated DNA damage
por: Giannini, Marta, et al.
Publicado: (2020)

Case Report: Laryngospasm as Initial Manifestation of Amyotrophic Lateral Sclerosis in a Long-Survival Patient With Heterozygous p.D90A – SOD1 Mutation
por: Capece, Giuliana, et al.
Publicado: (2021)

From Transcriptome to Noncoding RNAs: Implications in ALS Mechanism
por: Gagliardi, Stella, et al.
Publicado: (2012)

Reduced mitochondrial D-loop methylation levels in sporadic amyotrophic lateral sclerosis
por: Stoccoro, Andrea, et al.
Publicado: (2020)

PSEN1 Compound Heterozygous Mutations Associated with Cerebral Amyloid Angiopathy and Cognitive Decline Phenotype
por: Palmieri, Ilaria, et al.
Publicado: (2021)

Differential Neuropathology, Genetics, and Transcriptomics in Two Kindred Cases with Alzheimer’s Disease and Lewy Body Dementia
por: Palmieri, Ilaria, et al.
Publicado: (2022)

Long non coding RNAs and ALS: Still much to do
por: Gagliardi, Stella, et al.
Publicado: (2018)

Case Report: Novel Compound Heterozygous RNASEH2B Mutations Cause Aicardi–Goutières Syndrome
por: Garau, Jessica, et al.
Publicado: (2021)

Curcumin and Novel Synthetic Analogs in Cell-Based Studies of Alzheimer’s Disease
por: Gagliardi, Stella, et al.
Publicado: (2018)

Biomaterials in Neurodegenerative Disorders: A Promising Therapeutic Approach
por: Bordoni, Matteo, et al.
Publicado: (2020)

COVID‐19‐related neuropathology and microglial activation in elderly with and without dementia
por: Poloni, Tino Emanuele, et al.
Publicado: (2021)

Muscle cells of sporadic amyotrophic lateral sclerosis patients secrete neurotoxic vesicles
por: Le Gall, Laura, et al.
Publicado: (2022)

Muscle cells and motoneurons differentially remove mutant SOD1 causing familial amyotrophic lateral sclerosis
por: Onesto, Elisa, et al.
Publicado: (2011)

Neurodegenerative Disease-Associated TDP-43 Fragments Are Extracellularly Secreted with CASA Complex Proteins
por: Casarotto, Elena, et al.
Publicado: (2022)

Homocysteine, Folic Acid, Cyanocobalamin, and Frailty in Older People: Findings From the “Invece. Ab” Study
por: Guaita, Antonio, et al.
Publicado: (2021)

Inflammation and cell-to-cell communication, two related aspects in frailty
por: Pansarasa, Orietta, et al.
Publicado: (2022)

Multiple Roles of Transforming Growth Factor Beta in Amyotrophic Lateral Sclerosis
por: Galbiati, Mariarita, et al.
Publicado: (2020)

Hydroxychloroquine modulates immunological pathways activated by RNA:DNA hybrids in Aicardi–Goutières syndrome patients carrying RNASEH2 mutations
por: Garau, Jessica, et al.
Publicado: (2021)

Genetic variability in sporadic amyotrophic lateral sclerosis
por: Van Daele, Sien Hilde, et al.
Publicado: (2023)

MRI Study of Paraspinal Muscles in Patients with Amyotrophic Lateral Sclerosis (ALS)
por: Diamanti, Luca, et al.
Publicado: (2020)

A motor neuron strategy to save time and energy in neurodegeneration: adaptive protein stoichiometry
por: Zucchi, Elisabetta, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_9foq0benspu7ups1sk0d1kjjor