Cholesterol: A Gatekeeper of Male Fertility?

Cholesterol is essential for mammalian cell functions and integrity. It is an important structural component maintaining the permeability and fluidity of the cell membrane. The balance between synthesis and catabolism of cholesterol should be tightly regulated to ensure normal cellular processes. Ma...

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Detalles Bibliográficos
Autores principales: Sèdes, Lauriane, Thirouard, Laura, Maqdasy, Salwan, Garcia, Manon, Caira, Françoise, Lobaccaro, Jean-Marc A., Beaudoin, Claude, Volle, David H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060264/
https://www.ncbi.nlm.nih.gov/pubmed/30072948
http://dx.doi.org/10.3389/fendo.2018.00369
Descripción
Sumario:Cholesterol is essential for mammalian cell functions and integrity. It is an important structural component maintaining the permeability and fluidity of the cell membrane. The balance between synthesis and catabolism of cholesterol should be tightly regulated to ensure normal cellular processes. Male reproductive function has been demonstrated to be dependent on cholesterol homeostasis. Here we review data highlighting the impacts of cholesterol homeostasis on male fertility and the molecular mechanisms implicated through the signaling pathways of some nuclear receptors.

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